State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300350, People's Republic of China.
Qiannan Medical College for Nationalities, Duyun 558000, People's Republic of China.
Int J Biol Macromol. 2024 Aug;275(Pt 2):133460. doi: 10.1016/j.ijbiomac.2024.133460. Epub 2024 Jun 28.
Cancer poses a significant threat to human health, and monotherapy frequently fails to achieve optimal therapeutic outcomes. Based on this premise, porphyran (PHP), a marine polysaccharide with immunomodulatory function, was used as a framework to coat gold nanorods and construct a novel nanomedicine (PHP-MPBA-GNRs) combining photothermal therapy and immunotherapy. In this design, PHP not only maintained the dispersion stability and photothermal stability of gold nanorods but also could be released under weakly acidic conditions to activate anti-tumor immunity. In vivo studies have shown that PHP-MPBA-GNRs can effectively inhibit tumor cell proliferation and reduce metastasis under near-infrared (NIR) light irradiation. Preliminary mechanistic investigations revealed that PHP-MPBA-GNRs could increase reactive oxygen species (ROS) and induce apoptosis in cancer cells. The PHP in PHP-MPBA-GNRs can also activate dendritic cells and up-regulate the expression of co-stimulatory molecules and antigen-presenting complexes. All biological experiments, including in vivo tests, demonstrated that PHP-MPBA-GNRs achieved a combination of photothermal therapy and immunotherapy for tumors.
癌症对人类健康构成重大威胁，单药治疗往往无法达到最佳的治疗效果。基于这一前提，具有免疫调节功能的海洋多糖卟啉（PHP）被用作框架，包覆金纳米棒，构建了一种结合光热疗法和免疫疗法的新型纳米药物（PHP-MPBA-GNRs）。在该设计中，PHP 不仅保持了金纳米棒的分散稳定性和光热稳定性，而且可以在弱酸性条件下释放，从而激活抗肿瘤免疫。体内研究表明，PHP-MPBA-GNRs 在近红外（NIR）光照射下可以有效抑制肿瘤细胞增殖并减少转移。初步的机制研究表明，PHP-MPBA-GNRs 可以增加活性氧（ROS）并诱导癌细胞凋亡。PHP-MPBA-GNRs 中的 PHP 还可以激活树突状细胞，并上调共刺激分子和抗原呈递复合物的表达。所有的生物学实验，包括体内测试，都证明了 PHP-MPBA-GNRs 实现了肿瘤的光热疗法和免疫疗法的结合。
