Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, China.
Department of Oncology, Innovative Cancer Drug Research and Engineering Center of Liaoning Province, Cancer Stem Cell and Translational Medicine Laboratory, Shengjing Hospital of China Medical University, Shenyang 110000, China.
J Colloid Interface Sci. 2025 Jan 15;678(Pt C):272-282. doi: 10.1016/j.jcis.2024.09.100. Epub 2024 Sep 11.
Cancer immunotherapy has emerged as a potent treatment strategy by harnessing the host immune system to target cancer cells. However, challenges including low tumor vaccine immunogenicity and tumor heterogeneity hinder its clinical efficacy. To address these issues, we propose a novel nanoplatform integrating photothermal material gold nanorods (GNRs) with polyphenols for enhanced immunotherapy efficacy via photothermal therapy. Polyphenols, natural compounds with phenolic hydroxyl groups, are known for their ability to bind tightly to various molecules, making them ideal for antigen capture. We synthesized GNRs modified with polyphenols (GNR-PA and GNR-GA) and demonstrated their ability to induce immunogenic cell death upon laser irradiation, releasing tumor-associated antigens (TAAs). The surface polyphenols on GNRs effectively captured released TAAs to shield them from clearance. In vivo studies confirmed increased accumulation of GNR-GA in lymph nodes and enhanced dendritic cell maturation, leading to promoted effector T cell infiltration into tumors. Furthermore, treatment combined with PD-1/PD-L1 pathway blockade demonstrated potent tumor regression and systemic immunotherapy efficacy. Our findings highlight the potential of this photothermal nanoplatform as a promising strategy to overcome the limitations of current cancer immunotherapy approaches and improve therapeutic outcomes.
癌症免疫疗法通过利用宿主免疫系统来靶向癌细胞，已成为一种有效的治疗策略。然而，包括肿瘤疫苗免疫原性低和肿瘤异质性在内的挑战，限制了其临床疗效。为了解决这些问题，我们提出了一种新的纳米平台，将光热材料金纳米棒（GNRs）与多酚结合在一起，通过光热疗法增强免疫治疗效果。多酚是一种具有酚羟基的天然化合物，以其能够与各种分子紧密结合的能力而闻名，使其成为抗原捕获的理想选择。我们合成了用多酚修饰的 GNRs（GNR-PA 和 GNR-GA），并证明它们在激光照射下能够诱导免疫原性细胞死亡，释放肿瘤相关抗原（TAAs）。GNR 表面的多酚有效地捕获了释放的 TAAs，防止它们被清除。体内研究证实，GNR-GA 在淋巴结中的积累增加，并促进树突状细胞成熟，从而促进效应 T 细胞浸润肿瘤。此外，联合 PD-1/PD-L1 通路阻断的治疗显示出强大的肿瘤消退和全身免疫治疗效果。我们的研究结果强调了这种光热纳米平台作为一种有前途的策略的潜力，可克服当前癌症免疫治疗方法的局限性，并改善治疗效果。
