Tadjong Tcho Alain, Djouaka Bavoua Judith Liliane, Ngouonpe Wembe Alain, Gompe Bobda Eric Gustave, Majoumo Felicite, Leuche Joelle Merveilles, Ndonfack Tiofack Emmanuelle, Mbah James Ajeck, Toze Flavien Aristide Alfred
Department of Chemistry, Faculty of Sciences, University of Buea, Buea, Cameroon.
Department of Chemistry, Faculty of Science, University of Bamenda, Bamenda, Cameroon.
Nat Prod Res. 2024 Jul 1:1-11. doi: 10.1080/14786419.2024.2364258.
The chemical investigation of the methanol trunk bark extract of led to the isolation of a new flavanone, 5,7,4'-trihydroxy-3',5'-bis(3-methylbutadienyl)flavanone (trivially named senegalensisnone) (), together with seven known compounds, abyssinone-V-4'--methyl ether (), abyssinone V (), Calopocarpin (), genistein ) mixture of stigmasterol () and -sitosterol () and -sitosterol-3---D-glucopyranoside (). The structures of the isolates were elucidated by extensive spectroscopic and spectrometric analyses (1D and 2D NMR, ESI-MS) and by comparison with previously reported data. The absolute configuration of was deduced based on comparison of its experimental CD with that of similar compound. All the compounds were tested for their antibacterial, antifungal and antioxidant activities. Compound displayed weak antibacterial activity against with MIC value of 62.5 g/mL. All the isolates were found to be inactive as antioxidant agents in the DPPH, ABTS and FRAP assays.
对[植物名称]甲醇树干皮提取物进行化学研究，从中分离出一种新的黄烷酮，即5,7,4'-三羟基-3',5'-双(3-甲基丁二烯基)黄烷酮（俗名塞内加尔酮）（），以及七种已知化合物，阿比西酮-V-4'-O-甲基醚（）、阿比西酮V（）、卡洛波卡平（）、染料木黄酮（）、豆甾醇（）和β-谷甾醇（）的混合物以及β-谷甾醇-3-O-β-D-葡萄糖苷（）。通过广泛的光谱和波谱分析（一维和二维核磁共振、电喷雾电离质谱）以及与先前报道的数据进行比较，阐明了分离物的结构。通过将其实验圆二色性与类似化合物的圆二色性进行比较，推断出[化合物名称]的绝对构型。对所有化合物进行了抗菌、抗真菌和抗氧化活性测试。化合物对[细菌名称]显示出弱抗菌活性，最低抑菌浓度值为62.5μg/mL。在二苯基苦味酰基自由基（DPPH）、2,2'-联氮-双-3-乙基苯并噻唑啉-6-磺酸（ABTS）和铁还原抗氧化能力（FRAP）测定中，所有分离物均被发现作为抗氧化剂无活性。
