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钩藤属(卫矛科)中的生物活性成分。

Bioactive constituents from Hook.f. (Flacourtiaceae).

机构信息

Chemistry Laboratory, Department of Chemistry, Faculty of Science, University of Douala, Douala, Cameroon.

University Institute of Technology, University of Ngaoundere, Ngaoundere, Cameroon.

出版信息

Nat Prod Res. 2023 Nov-Dec;37(24):4188-4198. doi: 10.1080/14786419.2023.2177287. Epub 2023 Feb 12.

Abstract

The chemical investigation of the methanolic root extract of led to the isolation of a new arylbenzoate derivative, vogelinal (), together with thirteen known compounds (). The structures of the isolates were elucidated by extensive spectroscopic and spectrometric analyses (1D and 2D NMR, ESI-MS) and by comparison with previously reported data. All the compounds were tested for their antioxidant, antifungal and antibacterial activities. Compound exhibited the highest antioxidant potential, with RSaof 11.80 ± 2.13 µg/mL, RSaof 42.60 ± 6.32 µg/mL and RC of 51.60 ± 7.71 µg/mL for the DPPH, ABTS and FRAP assay, respectively. Compound displayed weak antifungal effect with MIC value of 125 μg/mL against . Compound showed weak antibacterial effect with MIC value of 125 μg/mL, against . The present study, conclude that this species could be a promising source of antioxidant and antibacterial constituents.

摘要

对 led 的甲醇根提取物的化学研究导致了一种新的芳基苯甲酸酯衍生物 vogelinal()的分离,以及十三种已知化合物()。通过广泛的光谱和光谱分析(1D 和 2D NMR、ESI-MS)以及与先前报道的数据进行比较,确定了分离物的结构。所有化合物均进行了抗氧化、抗真菌和抗菌活性测试。化合物()表现出最高的抗氧化潜力,其 DPPH、ABTS 和 FRAP 测定的 RSA 分别为 11.80±2.13μg/mL、42.60±6.32μg/mL 和 RC 为 51.60±7.71μg/mL。化合物()对 显示出较弱的抗真菌作用,MIC 值为 125μg/mL。化合物()对 显示出较弱的抗菌作用,MIC 值为 125μg/mL。本研究表明,该种可能是抗氧化和抗菌成分的有前途的来源。

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