Ndoumbe Tamba Charlemagne, Tsopgni Willifred Dongmo Tekapi, Fotso Bernard Samuel Hodjie, Longue Ekon Jean Pierre, Foundikou Nsangou Mohamed, Ngo Nyobe Judith Caroline, Sewald Norbert, Ndom Jean Claude
Chemistry Laboratory, Department of Chemistry, University of Douala, Douala, Cameroon.
Department of Organic Chemistry, University of Yaounde 1, Yaounde, Cameroon.
Nat Prod Res. 2025 Jan;39(1):9-19. doi: 10.1080/14786419.2023.2248351. Epub 2023 Aug 21.
The chemical investigation of the methanolic root extract of (P. Beauv.) Gilg exhibited two new 30-norfriedelane triterpenes, glaucalactones A and B (), together with eight known compounds, caloncobalactone (), friedelin (), friedelanol ), 3-oxo-friedelan-28-oic acid (), stigmasterol (), -sitosterol (), -sitosterol-3---D-glucopyranoside () and pentacosanoic acid (). The structures of the isolates were elucidated by extensive spectroscopic and spectrometric analyses (1D and 2D NMR, ESI-MS) and by comparison with previously reported data. All the compounds were tested for their antioxidant, antifungal and antibacterial activities. Compound displayed weak antibacterial effect with MIC value of 125 μg/mL against and . Compound exhibited moderated antifungal activity against with MIC value of 62.5 μg/mL. All the isolates were found to be inactive as antioxidants in the DPPH, ABTS and FRAP assays.
对（P. Beauv.）吉尔格甲醇根提取物的化学研究显示出两种新的30-降羽扇豆烷三萜类化合物，即 glaucalactones A和B（），以及八种已知化合物，caloncobalactone（）、木栓酮（）、木栓醇（）、3-氧代-羽扇豆-28-酸（）、豆甾醇（）、β-谷甾醇（）、β-谷甾醇-3-O-β-D-葡萄糖苷（）和二十五烷酸（）。通过广泛的光谱和波谱分析（一维和二维核磁共振、电喷雾电离质谱）并与先前报道的数据进行比较，阐明了分离物的结构。对所有化合物进行了抗氧化、抗真菌和抗菌活性测试。化合物对 和 显示出微弱的抗菌作用，其最低抑菌浓度（MIC）值为125μg/mL。化合物对 表现出中等程度的抗真菌活性，MIC值为62.5μg/mL。在二苯基苦味酰基自由基（DPPH）、2,2'-联氮-双-3-乙基苯并噻唑啉-6-磺酸（ABTS）和铁还原抗氧化能力（FRAP）测定中，所有分离物均无抗氧化活性。
