• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

生长与分化因子在视网膜发育中的基因调控作用。

Gene regulatory roles of growth and differentiation factors in retinal development.

作者信息

Luo Ziming, Shah Sahil, Tanasa Bogdan, Chang Kun-Che, Goldberg Jeffrey L

机构信息

Spencer Center for Vision Research, Byers Eye Institute, Stanford University School of Medicine, Palo Alto, CA 94304, USA.

Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA.

出版信息

iScience. 2024 May 24;27(6):110100. doi: 10.1016/j.isci.2024.110100. eCollection 2024 Jun 21.

DOI:10.1016/j.isci.2024.110100
PMID:38947520
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11214324/
Abstract

Retinal ganglion cell (RGC) differentiation is tightly controlled by extrinsic and intrinsic factors. Growth and differentiation factor 15 (GDF-15) promotes RGC differentiation, opposite to GDF-11 which inhibits RGC differentiation, both in the mouse retina and in human stem cells. To deepen our understanding of how these two closely related molecules confer opposing effects on retinal development, here we assess the transcriptional profiles of mouse retinal progenitors exposed to exogenous GDF-11 or -15. We find a dichotomous effect of GDF-15 on RGC differentiation, decreasing RGCs expressing residual pro-proliferative genes and increasing RGCs expressing non-proliferative genes, suggestive of greater RGC maturation. Furthermore, GDF-11 promoted the differentiation of photoreceptors and amacrine cells. These data enhance our understanding of the mechanisms underlying the differentiation of RGCs and photoreceptors from retinal progenitors and suggest new approaches to the optimization of protocols for the differentiation of these cell types.

摘要

视网膜神经节细胞（RGC）的分化受到外在和内在因素的严格控制。在小鼠视网膜和人类干细胞中，生长分化因子15（GDF-15）促进RGC分化，而GDF-11则抑制RGC分化，二者作用相反。为了更深入地了解这两种密切相关的分子如何对视网膜发育产生相反的影响，我们在此评估了暴露于外源性GDF-11或-15的小鼠视网膜祖细胞的转录谱。我们发现GDF-15对RGC分化有二分效应，减少表达残留增殖相关基因的RGC数量，增加表达非增殖相关基因的RGC数量，这表明RGC成熟度更高。此外，GDF-11促进了光感受器和无长突细胞的分化。这些数据加深了我们对视网膜祖细胞分化为RGC和光感受器的潜在机制的理解，并为优化这些细胞类型分化方案提供了新方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a98/11214324/7a7c9b58b5d3/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a98/11214324/c6dee9340184/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a98/11214324/058ac48a6536/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a98/11214324/68ad5c1bd76b/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a98/11214324/c270d3e508ab/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a98/11214324/d794ade9cfcc/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a98/11214324/7a7c9b58b5d3/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a98/11214324/c6dee9340184/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a98/11214324/058ac48a6536/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a98/11214324/68ad5c1bd76b/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a98/11214324/c270d3e508ab/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a98/11214324/d794ade9cfcc/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a98/11214324/7a7c9b58b5d3/gr5.jpg

相似文献

1
Gene regulatory roles of growth and differentiation factors in retinal development.生长与分化因子在视网膜发育中的基因调控作用。
iScience. 2024 May 24;27(6):110100. doi: 10.1016/j.isci.2024.110100. eCollection 2024 Jun 21.
2
Opposing Effects of Growth and Differentiation Factors in Cell-Fate Specification.生长分化因子在细胞命运特化中的拮抗作用。
Curr Biol. 2019 Jun 17;29(12):1963-1975.e5. doi: 10.1016/j.cub.2019.05.011. Epub 2019 May 30.
3
Math5 determines the competence state of retinal ganglion cell progenitors.Math5决定视网膜神经节细胞祖细胞的分化能力状态。
Dev Biol. 2003 Dec 1;264(1):240-54. doi: 10.1016/j.ydbio.2003.08.005.
4
Strip1 regulates retinal ganglion cell survival by suppressing Jun-mediated apoptosis to promote retinal neural circuit formation.Strip1 通过抑制 Jun 介导的细胞凋亡来调节视网膜神经节细胞的存活，从而促进视网膜神经回路的形成。
Elife. 2022 Mar 22;11:e74650. doi: 10.7554/eLife.74650.
5
A comprehensive negative regulatory program controlled by Brn3b to ensure ganglion cell specification from multipotential retinal precursors.由Brn3b控制的全面负调控程序，以确保多能视网膜前体细胞分化为神经节细胞。
J Neurosci. 2008 Mar 26;28(13):3392-403. doi: 10.1523/JNEUROSCI.0043-08.2008.
6
Allogeneic Transplantation of Müller-Derived Retinal Ganglion Cells Improves Retinal Function in a Feline Model of Ganglion Cell Depletion.缪勒源性视网膜神经节细胞的同种异体移植改善神经节细胞缺失猫模型的视网膜功能。
Stem Cells Transl Med. 2016 Feb;5(2):192-205. doi: 10.5966/sctm.2015-0125. Epub 2015 Dec 30.
7
Temporal expression of CD184(CXCR4) and CD171(L1CAM) identifies distinct early developmental stages of human retinal ganglion cells in embryonic stem cell derived retina.CD184（CXCR4）和CD171（L1CAM）的时序表达确定了胚胎干细胞来源视网膜中人类视网膜神经节细胞不同的早期发育阶段。
Exp Eye Res. 2017 Jan;154:177-189. doi: 10.1016/j.exer.2016.11.013. Epub 2016 Nov 17.
8
Genetic control of retinal ganglion cell genesis.视网膜神经节细胞发生的遗传控制。
Cell Mol Life Sci. 2021 May;78(9):4417-4433. doi: 10.1007/s00018-021-03814-w. Epub 2021 Mar 29.
9
Effect of p75NTR on the regulation of naturally occurring cell death and retinal ganglion cell number in the mouse eye.p75神经营养因子受体对小鼠眼睛中自然发生的细胞死亡及视网膜神经节细胞数量调节的影响。
Dev Biol. 2006 Feb 1;290(1):57-65. doi: 10.1016/j.ydbio.2005.08.051. Epub 2005 Dec 15.
10
Characterization of retinal ganglion cell, horizontal cell, and amacrine cell types expressing the neurotrophic receptor tyrosine kinase Ret.表达神经营养受体酪氨酸激酶Ret的视网膜神经节细胞、水平细胞和无长突细胞类型的特征分析
J Comp Neurol. 2018 Mar 1;526(4):742-766. doi: 10.1002/cne.24367. Epub 2017 Dec 19.

本文引用的文献

1
Role of growth differentiation factor 15 in cancer cachexia (Review).生长分化因子15在癌症恶病质中的作用（综述）
Oncol Lett. 2023 Sep 13;26(5):462. doi: 10.3892/ol.2023.14049. eCollection 2023 Nov.
2
Diversification of multipotential postmitotic mouse retinal ganglion cell precursors into discrete types.多潜能有丝分裂后小鼠视网膜神经节细胞前体细胞向离散型的分化。
Elife. 2022 Feb 22;11:e73809. doi: 10.7554/eLife.73809.
3
Elevated Levels of Growth/Differentiation Factor-15 in the Aqueous Humor and Serum of Glaucoma Patients.青光眼患者房水和血清中生长/分化因子-15水平升高。
J Clin Med. 2022 Jan 29;11(3):744. doi: 10.3390/jcm11030744.
4
Regeneration of Ganglion Cells for Vision Restoration in Mammalian Retinas.哺乳动物视网膜中用于视力恢复的神经节细胞再生
Front Cell Dev Biol. 2021 Oct 4;9:755544. doi: 10.3389/fcell.2021.755544. eCollection 2021.
5
Genetic interplay between transcription factor Pou4f1/Brn3a and neurotrophin receptor Ret in retinal ganglion cell type specification.转录因子 Pou4f1/Brn3a 和神经营养因子受体 Ret 在视网膜神经节细胞类型特化中的遗传相互作用。
Neural Dev. 2021 Sep 21;16(1):5. doi: 10.1186/s13064-021-00155-z.
6
Retinal Ganglion Cell Transplantation: Approaches for Overcoming Challenges to Functional Integration.视网膜神经节细胞移植：克服功能整合挑战的方法。
Cells. 2021 Jun 8;10(6):1426. doi: 10.3390/cells10061426.
7
Integrated analysis of multimodal single-cell data.多模态单细胞数据的综合分析。
Cell. 2021 Jun 24;184(13):3573-3587.e29. doi: 10.1016/j.cell.2021.04.048. Epub 2021 May 31.
8
Genetic control of retinal ganglion cell genesis.视网膜神经节细胞发生的遗传控制。
Cell Mol Life Sci. 2021 May;78(9):4417-4433. doi: 10.1007/s00018-021-03814-w. Epub 2021 Mar 29.
9
Atoh7-independent specification of retinal ganglion cell identity.视网膜神经节细胞身份的无Atoh7特异性分化
Sci Adv. 2021 Mar 12;7(11). doi: 10.1126/sciadv.abe4983. Print 2021 Mar.
10
Single cell transcriptomics reveals lineage trajectory of retinal ganglion cells in wild-type and Atoh7-null retinas.单细胞转录组学揭示了野生型和 Atoh7 缺失型视网膜中神经节细胞的谱系轨迹。
Nat Commun. 2021 Mar 5;12(1):1465. doi: 10.1038/s41467-021-21704-4.