Akanmode Abiodun M, Anwer Fatima, Kalloo Matthew, Redwood Eldon
Department of Medicine, Harlem Hospital Center, New York City, USA.
Cureus. 2024 May 31;16(5):e61434. doi: 10.7759/cureus.61434. eCollection 2024 May.
Histoplasma capsulatum is a dimorphic fungus that grows in nature as a mold or in culture but converts to a small yeast during cellular invasion. While most histoplasmosis infections are primarily asymptomatic or mildly symptomatic, disseminated histoplasmosis is a relentlessly progressive granulomatous disease that can mimic other granulomatous diseases, such as tuberculosis, sarcoidosis or coccidioidomycosis, more so in the proper context of immunosuppression. The current global migrant crisis, particularly the United States migrant crisis conversation is mostly socio-political; however, it also has a public health implication as exemplified by the case of a 35-year-old male who migrated from Haiti via Chile and Mexico to the United States. He presented with a four-day history of fever, generalized body aches, and cough. This case underscores the importance of entertaining a myriad of differentials and avoiding the tendency for anchoring, especially when initial therapy yields little clinical response.
荚膜组织胞浆菌是一种双相真菌,在自然界中以霉菌形式生长或在培养物中生长,但在细胞侵袭期间会转变为小酵母形式。虽然大多数组织胞浆菌病感染主要无症状或症状轻微,但播散性组织胞浆菌病是一种持续进展的肉芽肿性疾病,在免疫抑制的适当背景下,它更易与其他肉芽肿性疾病(如结核病、结节病或球孢子菌病)相混淆。当前的全球移民危机,特别是美国的移民危机讨论大多是社会政治层面的;然而,它也具有公共卫生意义,例如一名35岁男性从海地经智利和墨西哥移民到美国的案例。他出现了四天的发热、全身酸痛和咳嗽病史。该病例强调了考虑多种鉴别诊断并避免锚定倾向的重要性,尤其是在初始治疗几乎没有临床反应时。