印度急性淋巴细胞白血病的亚型模式。

Pattern of subtypes of acute lymphoblastic leukemia in India.

作者信息

Kamat D M, Gopal R, Advani S H, Nair C N, Kumar A, Saikia T, Nadkarni J J, Nadkarni J S

出版信息

Leuk Res. 1985;9(7):927-34. doi: 10.1016/0145-2126(85)90315-7.

Abstract

Leukemic cells from 124 acute lymphoblastic leukemia (ALL) and 31 chronic lymphatic leukemia (CLL) were examined for sheep erythrocyte receptor (E), surface immunoglobulin (SIg) and their reactivity with a panel of monoclonal antibodies recognizing specific surface antigens including pan-T, Common ALL and Ia antigens. In acute lymphatic leukemia, 33% of patients reveal T-cell receptor associated with higher age group, mediastinal mass and high WBC count. Common ALL was predominant between 2 and 9-yr age group. Among chronic lymphatic leukemia, 2 patients were found to be T-CLL while 29 revealed presence of SIg. Ia antigen was detected in 44.4% of ALL and 64% fo CLL patients. The pattern of surface marker observed in our series may be related to our life style, socio-economic and environmental factors.

摘要

对124例急性淋巴细胞白血病（ALL）和31例慢性淋巴细胞白血病（CLL）的白血病细胞进行了检测，以观察其对绵羊红细胞受体（E）、表面免疫球蛋白（SIg）以及它们与一组识别特定表面抗原（包括泛T、普通ALL和Ia抗原）的单克隆抗体的反应性。在急性淋巴细胞白血病中，33%的患者显示T细胞受体与较高年龄组、纵隔肿块和高白细胞计数相关。普通ALL在2至9岁年龄组中占主导地位。在慢性淋巴细胞白血病中，发现2例为T-CLL，而29例显示存在SIg。44.4%的ALL患者和64%的CLL患者检测到Ia抗原。在我们的研究系列中观察到的表面标志物模式可能与我们的生活方式、社会经济和环境因素有关。