Malcolm Jennifer, Culshaw Shauna
Oral Sciences, University of Glasgow Dental School, School of Medicine, Dentistry and Nursing, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.
Front Oral Health. 2024 Jun 14;5:1430886. doi: 10.3389/froh.2024.1430886. eCollection 2024.
There are well established epidemiological links between rheumatoid arthritis and periodontitis. Recent data have started to shed light on the mechanisms that might underlie the relationship between these two complex diseases. Unravelling the roles of distinct pathways involved in these mechanisms has the potential to yield novel preventative and therapeutic strategies for both diseases. Perhaps most intriguingly, this represents an area where understanding the biology in the oral cavity might reveal fundamental advances in understanding immune regulation and the relationships between the host and microbiome. Here we seek to discuss aspects of the adaptive immune response that might link periodontitis and rheumatoid arthritis.
类风湿性关节炎与牙周炎之间存在着已得到充分证实的流行病学关联。近期的数据已开始揭示这两种复杂疾病之间关系可能潜在的机制。阐明这些机制中不同途径所起的作用，有可能为这两种疾病带来新的预防和治疗策略。或许最引人入胜的是，这代表了一个领域，即了解口腔生物学可能会揭示在理解免疫调节以及宿主与微生物群之间关系方面的根本性进展。在此，我们试图讨论可能将牙周炎和类风湿性关节炎联系起来的适应性免疫反应的各个方面。
