Kriauciunas Albertas, Gleiznys Alvydas, Gleiznys Darius, Janužis Gintaras
Dental and Maxillofacial Orthopedics, Lithuanian University of Health Sciences, Kaunas, LTU.
Maxillofacial Surgery, Lithuanian University of Health Sciences, Kaunas, LTU.
Cureus. 2019 May 28;11(5):e4775. doi: 10.7759/cureus.4775.
Periodontal pathologies are highly widespread throughout the world. Epidemiological studies have shown that as much as 1% of the population is suffering from periodontal disease. In recent years, there has been a growing number of studies linking these diseases with autoimmune diseases, especially with rheumatoid arthritis. This literature review evaluates changes in the relationship between periodontal pathologies caused by the bacterium Porphyromonas gingivalis and rheumatoid arthritis. The systematic review of the literature was performed according to the PRISMA analysis protocol. The review was performed with articles from the PubMed database. Searched articles were not older than 5 years. Only full texts and research performed with people were selected. A total of 56 results were received. A review and analysis of their full texts have been carried out and 10 articles were selected according to the established criteria. They were analyzed and results were presented. The results obtained from the literature were based on the influence of Porphyromonas gingivalis on the pathogenesis of rheumatoid arthritis. In the literature, the activity of this bacterium is explained by the analysis of its enzyme peptidylarginine deiminase and its principle of action. Studies have also been found to prove the presence of Porphyromonas gingivalis not only in the oral cavity but its DNA is also found in synovial fluid and plasma. In the researched articles, direct links between Porphyromonas gingivalis and rheumatoid arthritis have led doctors to draw attention to patients' oral hygiene and the condition of parodentium, as this may be the cause of autoimmune lesions. Treatment of periodontal disease will not only help maintain a healthy oral cavity but prevent the spread of bacteria to the surrounding tissues.
牙周病在全球范围内高度普遍。流行病学研究表明，多达1%的人口患有牙周疾病。近年来，越来越多的研究将这些疾病与自身免疫性疾病联系起来，尤其是与类风湿性关节炎。这篇文献综述评估了由牙龈卟啉单胞菌引起的牙周病与类风湿性关节炎之间关系的变化。根据PRISMA分析方案对文献进行了系统综述。该综述使用了来自PubMed数据库的文章。检索的文章不早于5年。仅选择全文以及针对人类开展的研究。共获得56条结果。对其全文进行了综述和分析，并根据既定标准选择了10篇文章。对它们进行了分析并呈现了结果。从文献中获得的结果基于牙龈卟啉单胞菌对类风湿性关节炎发病机制的影响。在文献中，通过对其肽基精氨酸脱亚氨酶及其作用原理的分析来解释这种细菌的活性。研究还发现，不仅在口腔中存在牙龈卟啉单胞菌，在滑液和血浆中也发现了其DNA。在这些研究文章中，牙龈卟啉单胞菌与类风湿性关节炎之间的直接联系使医生们关注患者的口腔卫生和牙周状况，因为这可能是自身免疫性病变的原因。治疗牙周病不仅有助于保持口腔健康，还能防止细菌扩散到周围组织。
