Rahman Mahbubur, Sultana Jesmin, Hasan Shaikh Sharif, Nurunnahar Syeda, Baker Musa, Raqib Rubhana, Rahman Syed Moshfiqur, Kippler Maria, Parvez Sarker Masud
Global Health and Migration Unit, Department of Women's and Children's Health, Uppsala University, Sweden.
Environmental Health and WASH, Health System and Population Studies Division, icddr,b, Mohakhali, Dhaka, 1212, Bangladesh.
MethodsX. 2024 May 29;12:102772. doi: 10.1016/j.mex.2024.102772. eCollection 2024 Jun.
Lead (Pb) is a neurotoxin, and children are vulnerable due to their evolving physiology and high-risk behaviours. Soil remediation interventions have proven effective in reducing Pb exposure. The primary objective is to measure the effectiveness of soil remediation at abandoned used lead acid battery (ULAB) recycling sites, nearby household cleaning, and community awareness in reducing blood lead levels (BLLs) in children. Additionally, this study aims to examine associations of Pb exposure with hematological, cardiovascular, renal, immunological, and endocrinological parameters in children aged 0-12 years. This study employs a quasi-experimental design, with abandoned ULAB sites as intervention sites and two control sites in Bangladesh. The intervention includes soil remediation coupled with community education. Data will be collected prior to the intervention and at a 12-month follow-up, including a comprehensive Pb exposure survey and collect environmental, turmeric samples, and blood from the child. Pb concentrations in environmental samples and turmeric samples will be determined using XRF analyser. Child BLL will be measured using Graphite Furnace Atomic Absorption Spectrometry (GF-AAS) and proposed biochemical parameters will be analysed using routine laboratory methods. This study could provide valuable insights for designing targeted interventions in similar settings and mitigating exposure to Pb.
铅(Pb)是一种神经毒素,由于儿童不断发育的生理机能和高风险行为,他们很容易受到影响。土壤修复干预措施已被证明在减少铅暴露方面有效。主要目标是衡量在废弃的铅酸蓄电池(ULAB)回收场地进行土壤修复、周边家庭清洁以及提高社区意识对降低儿童血铅水平(BLL)的效果。此外,本研究旨在调查0至12岁儿童铅暴露与血液学、心血管、肾脏、免疫和内分泌参数之间的关联。本研究采用准实验设计,将废弃的ULAB场地作为干预地点,并在孟加拉国设置两个对照地点。干预措施包括土壤修复和社区教育。将在干预前和12个月随访时收集数据,包括全面的铅暴露调查,并采集环境样本、姜黄样本以及儿童的血液。环境样本和姜黄样本中的铅浓度将使用X射线荧光光谱分析仪(XRF)测定。儿童血铅水平将使用石墨炉原子吸收光谱法(GF-AAS)测量,拟议的生化参数将使用常规实验室方法进行分析。本研究可为在类似环境中设计针对性干预措施以及减轻铅暴露提供宝贵见解。