Hu Peiran, Pan Jiexue, Liu Xinmei, Huang Hefeng
（ 200030） Obstetrics and Gynecology Hospital, Institute of Reproduction and Development, Fudan University, Shanghai 200030, China.
（ 200030） Shanghai Key Laboratory of Reproduction and Development, Shanghai 200030, China.
Sichuan Da Xue Xue Bao Yi Xue Ban. 2024 May 20;55(3):501-506. doi: 10.12182/20240560401.
Assisted reproductive technologies (ARTs) are core components of the field of reproductive medicine, encompassing multiple pivotal stages of early development from gamete maturation and fertilization to embryo development. Against the backdrop of a deteriorating trend of global decline in fertility rates, patients with infertility problems increasingly turn to ARTs to realize their dreams of parenthood. However, concomitant with this trend is a growing apprehension regarding the potential adverse effects of ARTs. Herein, we endeavor to discuss several common ARTs procedures utilized in clinical settings and the relevant cutting-edge advancements. The ARTs discussed in the article include fertilization (IVF), intracytoplasmic sperm injection (ICSI), biphasic maturation (biphasic IVM), frozen embryo transfer (FET), preimplantation genetic testing (PGT), non-invasive PGT (niPGT), etc. In addition, we reevaluated their roles within the broader context of assisted reproduction aimed at promoting reproductive health. Additionally, we will delve into the impact of ARTs on the reproductive health of the offspring. By prioritizing the reproductive well-being of both patients and their offspring, the ongoing development and improvement of ARTs to enhance their efficacy and safety will contribute significantly to the advancement of human reproductive health.
辅助生殖技术（ARTs）是生殖医学领域的核心组成部分，涵盖了从配子成熟、受精到胚胎发育等早期发育的多个关键阶段。在全球生育率呈下降趋势的背景下，不孕不育患者越来越多地求助于辅助生殖技术来实现为人父母的梦想。然而，伴随着这一趋势的是人们对辅助生殖技术潜在不良影响的担忧日益增加。在此，我们努力探讨临床中使用的几种常见辅助生殖技术程序以及相关的前沿进展。本文讨论的辅助生殖技术包括体外受精（IVF）、卵胞浆内单精子注射（ICSI）、双相成熟（双相IVM）、冷冻胚胎移植（FET）、植入前基因检测（PGT）、无创PGT（niPGT）等。此外，我们在旨在促进生殖健康的辅助生殖更广泛背景下重新评估了它们的作用。此外，我们将深入探讨辅助生殖技术对后代生殖健康的影响。通过优先考虑患者及其后代的生殖福祉，不断发展和改进辅助生殖技术以提高其疗效和安全性将对人类生殖健康的进步做出重大贡献。
