Liu Xuyao, Shi Qi, Qi Peng, Wang Ziming, Zhang Tongyue, Zhang Sijia, Wu Jiayan, Guo Zhaopei, Chen Jie, Zhang Qiang
Department of Thyroid Surgery, General Surgery Center, The First Hospital of Jilin University, Changchun 130021, China.
Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China.
Asian J Pharm Sci. 2024 Jun;19(3):100910. doi: 10.1016/j.ajps.2024.100910. Epub 2024 Apr 13.
The early diagnosis of cancer is vital for effective treatment and improved prognosis. Tumor biomarkers, which can be used for the early diagnosis, treatment, and prognostic evaluation of cancer, have emerged as a topic of intense research interest in recent years. Nucleic acid, as a type of tumor biomarker, contains vital genetic information, which is of great significance for the occurrence and development of cancer. Currently, living cell nucleic acid probes, which enable the imaging and dynamic monitoring of nucleic acids, have become a rapidly developing field. This review focuses on living cell nucleic acid probes that can be used for the early diagnosis of tumors. We describe the fundamental design of the probe in terms of three units and focus on the roles of different nanomaterials in probe delivery.
癌症的早期诊断对于有效治疗和改善预后至关重要。肿瘤生物标志物可用于癌症的早期诊断、治疗和预后评估，近年来已成为研究热点。核酸作为一种肿瘤生物标志物，包含重要的遗传信息，对癌症的发生发展具有重要意义。目前，能够对核酸进行成像和动态监测的活细胞核酸探针已成为一个快速发展的领域。本文综述了可用于肿瘤早期诊断的活细胞核酸探针。我们从三个单元描述了探针的基本设计，并重点介绍了不同纳米材料在探针递送中的作用。
