Medical School, Huanghe Science & Technology College, Zhengzhou, PR China.
Key Laboratory of Tropical Translational Medicine of Ministry of Education, Hainan Provincial Key Lab of R&D on Tropic Herbs, School of Pharmacy, Hainan Medical University, Haikou, PR China.
Pak J Pharm Sci. 2023 Mar;36(2):557-564.
Alpinia oxyphylla Fructus is one of the traditional Chinese medicine plants in the treatment of kidney injury. In clinical practice, crude Alpinia oxyphylla Fructus (CAOF) and salt-processed Alpinia oxyphylla Fructus (SAOF) are the two commonly used drugs specificated in the prevention and treatment of diabetic nephropathy (DN). However, the intestinal micro ecology regulation between CAOF and SAOF on DN has not been reported. In this paper, intestinal micro ecology regulation activities between CAOF and SAOF in DN rats were compared and analyzed by short-chain fatty acids (SCFAs) and intestinal flora analysis. The results showed that both SAOF and CAOF can regulate the intestinal flora metabolite SCFAs level in DN rats, reduce blood glucose concentration and improve inflammatory reaction. The intestinal flora analysis showed SAOF and CAOF could increase the intestinal bacterial diversity. The treatment of renal injury may be related to their increased intestinal bacterial diversity.
益智果实是治疗肾损伤的中药之一。在临床实践中，生益智果（CAOF）和盐制益智果（SAOF）是预防和治疗糖尿病肾病（DN）的两种常用药物。然而，CAOF 和 SAOF 对 DN 的肠道微生态调节尚未见报道。本研究通过短链脂肪酸（SCFAs）和肠道菌群分析比较和分析了 CAOF 和 SAOF 对 DN 大鼠肠道微生态调节的作用。结果表明，SAOF 和 CAOF 均可调节 DN 大鼠肠道菌群代谢物 SCFAs 水平，降低血糖浓度，改善炎症反应。肠道菌群分析表明，SAOF 和 CAOF 可增加肠道细菌多样性。治疗肾损伤可能与其增加肠道细菌多样性有关。
