Department of Rheumatology, Foundation University Medical College, Foundation University, Islamabad, Pakistan.
Department of Rheumatology, Rheumatology Foundation University Medical College, Fauji Foundation Hospital, Rawalpindi, Pakistan.
J Pak Med Assoc. 2024 Jun;74(6):1055-1060. doi: 10.47391/JPMA.9371.
To determine the effect of disease activity on clinical outcomes of coronavirus disease-2019 in patients with rheumatic diseases.
The prospective, cohort study was conducted from January 1st to June 30th, 2021, at Rheumatology department, Fauji Foundation Hospital, Rawalpindi. It comprised patients of rheumatic disorders who were affected by coronavirus disease-2019. The patients were categorised according to rheumatic disease activity into remission group I, low disease activity group II, moderate group III and high-activity group IV. Coronavirus disease-2019 outcomes compared included recovered vs death, hospitalisation yes vs no, mechanical ventilation yes vs no. The association of disease activity status with coronavirus disease-2019 outcomes was explored. Data was analysed using SPSS 23.
Of the 100 patients, 78(78%) were females and 22(22%) were males. The overall mean age was 45.60±13.7 years. There were 23(23%) patients in group I, 42(42%) patients in group II, 21(21%) patients in group III and 14(14%) patients in group IV. Overall,17(17%) patients died and 83(83%) patients survived. In group III, 7(33.3%) patients died, followed by 6(42.9%) in group IV (p<0.05). In total, 7(7%) patients needed mechanical ventilation, with 3(21.4%) being in group IV (p<0.05). Hospitalisation was needed in 33(33%) cases, and intergroup comparison was non-significant (p>0.05).
Patients with severe rheumatic autoimmune disease affected by coronavirus disease-2019 were more likely to die and require invasive ventilation.
确定疾病活动度对风湿性疾病患者 2019 年冠状病毒病临床结局的影响。
这项前瞻性队列研究于 2021 年 1 月 1 日至 6 月 30 日在拉瓦尔品第的法乌吉基金会医院风湿病科进行，纳入了受 2019 年冠状病毒病影响的风湿性疾病患者。根据疾病活动度将患者分为缓解组 I、低疾病活动组 II、中组 III 和高活动组 IV。比较了 2019 年冠状病毒病的结局，包括康复与死亡、住院与未住院、机械通气与未通气。探讨了疾病活动状态与 2019 年冠状病毒病结局的关系。数据使用 SPSS 23 进行分析。
在 100 名患者中，78(78%)为女性，22(22%)为男性。总体平均年龄为 45.60±13.7 岁。I 组 23(23%)例，II 组 42(42%)例，III 组 21(21%)例，IV 组 14(14%)例。共有 17(17%)名患者死亡，83(83%)名患者存活。在 III 组中，7(33.3%)名患者死亡，其次是 IV 组的 6(42.9%)(p<0.05)。总共 7(7%)名患者需要机械通气，其中 4(21.4%)例在 IV 组(p<0.05)。需要住院治疗的患者有 33(33%)例，组间比较无显著性差异(p>0.05)。
受 2019 年冠状病毒病影响的严重风湿性自身免疫性疾病患者更有可能死亡并需要侵入性通气。
