Yang Mengqian, Chen Dandan, Zhang Li, Ye Miantai, Song Yuchen, Xu Jiaqing, Cao Yu, Liu Zhihong
College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, China.
College of Health Science and Engineering, Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules, Hubei University, Wuhan 430062, P. R. China.
ACS Appl Mater Interfaces. 2024 Jul 17;16(28):35925-35935. doi: 10.1021/acsami.4c03012. Epub 2024 Jul 1.
The development of efficient theranostic nanoagents for the precise diagnosis and targeted therapy of glioblastoma (GBM) remains a big challenge. Herein, we designed and developed porphyrin-based organic nanoparticles (PNP NPs) with strong emission in the near-infrared IIa window (NIR-IIa) for orthotopic GBM theranostics. PNP NPs possess favorable photoacoustic and photothermal properties, high photostability, and low toxicity. After modification with the RGD peptide, the obtained PNPD NPs exhibited enhanced blood-brain barrier (BBB) penetration capability and GBM targeting ability. NIR-IIa imaging was employed to monitor the biodistribution and accumulation of the nanoparticles, revealing a significant enhancement in penetration depth and signal-to-noise ratio. Both and results demonstrated that PNPD NPs effectively inhibited the proliferation of tumor cells and induced negligible side effects in normal brain tissues. In general, the work presented a kind of brain-targeted porphyrin-based NPs with NIR-IIa fluorescence for orthotopic glioblastoma theranostics, showing promising prospects for clinical translation.
开发用于胶质母细胞瘤（GBM）精确诊断和靶向治疗的高效诊疗纳米剂仍然是一个巨大的挑战。在此，我们设计并开发了基于卟啉的有机纳米颗粒（PNP NPs），其在近红外IIa窗口（NIR-IIa）具有强发射，用于原位GBM诊疗。PNP NPs具有良好的光声和光热性能、高光稳定性和低毒性。用RGD肽修饰后，所得的PNPD NPs表现出增强的血脑屏障（BBB）穿透能力和GBM靶向能力。采用NIR-IIa成像监测纳米颗粒的生物分布和积累，揭示了穿透深度和信噪比的显著提高。体外和体内结果均表明，PNPD NPs有效抑制肿瘤细胞增殖，对正常脑组织诱导的副作用可忽略不计。总体而言，该工作展示了一种用于原位胶质母细胞瘤诊疗的具有NIR-IIa荧光的脑靶向卟啉基纳米颗粒，具有临床转化的广阔前景。
