Department of Chemistry, Faculty of Science, Al-Azhar University, Assiut Branch, Assiut, 71524, Egypt.
Chemistry Department, Faculty of Science, Al-Azhar University, Nasr City-Cairo, 11884, Egypt.
Chem Biodivers. 2024 Oct;21(10):e202400644. doi: 10.1002/cbdv.202400644. Epub 2024 Aug 27.
Naturally occurring peroxides received great interest and attention from scientific research groups worldwide due to their structural diversity, versatile biological activities, and pharmaceutical properties. In the present review, we describe the historical discovery of natural peroxides from plants systematically and update the researchers with recently explored ones justifying their structural caterogrization and biological/pharmaceutical properties intensively. Till the end of 2023, 192 peroxy natural products from plants were documented herein for the first time implying most categories of natural scaffolds (e. g. terpenes, polyketides, phenolics and alkaloids). Numerically, the reported plants' peroxides have been classified into seventy-four hydro-peroxides, hundred seven endo-peroxides and eleven acyl-peroxides. Endo-peroxides (cyclic alkyl peroxides) are an important group due to their high variety of structural frameworks, and we have further divided them into "four-, five-, six and seven"-membered rings. Biosynthetically, a shedding light on the intricate mechanisms behind the formation of plant-derived peroxides are addressed as well.
天然过氧化物因其结构多样性、广泛的生物活性和药物特性，引起了全球科学研究小组的极大兴趣和关注。在本综述中，我们系统地描述了植物中天然过氧化物的历史发现，并为研究人员提供了最近探索的过氧化物，深入阐明了其结构分类和生物/药物特性。截至 2023 年底，本文首次记录了来自植物的 192 种过氧天然产物，涉及大多数天然支架类别（例如萜类、聚酮类、酚类和生物碱）。从数量上看，已报道的植物过氧化物分为七十四种氢过氧化物、一百零七种内过氧化物和十一种酰基过氧化物。内过氧化物（环状烷基过氧化物）是一个重要的类别，因为它们具有丰富的结构框架，我们进一步将它们分为“四、五、六和七”元环。从生物合成的角度来看，我们还探讨了植物来源的过氧化物形成背后复杂机制。
