N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky Prospect 47, Moscow, Russia, 119991.
Institute of Biomedical Chemistry, Moscow, Russia, 119121.
Appl Microbiol Biotechnol. 2018 Sep;102(18):7657-7667. doi: 10.1007/s00253-018-9211-2. Epub 2018 Jul 10.
Peroxides represent a large and interesting group of biologically active natural compounds. All these metabolites contain a peroxide group (R-O-O-R). This review describes studies of more than 60 peroxides isolated from plants and fungi. Most of the plant peroxy steroids exhibit high antiprotozoal (Plasmodium) activity with a confidence of up to 95%, while steroids harvested from fungi show more antineoplastic activity with a confidence of up to 94%. In addition, more than 20 different activities of both groups of peroxides with a probability of 78 to 90% have also been predicted using computer program PASS.
过氧化物是一大类具有生物活性的天然化合物，其中包含过氧基（R-O-O-R）。本综述描述了从植物和真菌中分离出的 60 多种过氧化物的研究。大多数植物过氧化物甾体具有很高的抗原虫（疟原虫）活性，置信度高达 95%，而从真菌中提取的甾体则具有更高的抗肿瘤活性，置信度高达 94%。此外，使用 PASS 计算机程序还预测了这两类过氧化物具有 78%至 90%概率的 20 多种不同活性。
