翻修鼻窦手术在度普利尤单抗治疗启动中的作用：分子和细胞特征的真实世界研究。
The role of revision sinus surgery in the initiation of dupilumab therapy: A real-world study of molecular and cellular features.
机构信息
Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
Department of Otolaryngology-Head & Neck Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
出版信息
Int Forum Allergy Rhinol. 2024 Oct;14(10):1647-1651. doi: 10.1002/alr.23401. Epub 2024 Jul 3.
Abstract
A persistent type 2 endotype signature exists in recalcitrant chronic rhinosinusitis with nasal polyps mucosa on dupilumab. Revision sinus surgery immediately prior to dupilumab reduces long-term interleukin (IL)-4/IL-13 tissue mRNA. Pre-dupilumab revision surgery is associated with reduced tissue eosinophils and GATA-3+ cells.
摘要
在接受度普利尤单抗治疗的难治性慢性鼻-鼻窦炎伴鼻息肉患者的鼻息肉组织中存在持续的 2 型固有免疫表型特征。在接受度普利尤单抗治疗之前进行鼻窦修正手术可降低组织中白细胞介素（IL）-4/IL-13 的 mRNA 水平。在接受度普利尤单抗治疗之前进行鼻窦修正手术与组织中嗜酸性粒细胞和 GATA-3+细胞减少有关。
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2
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3
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J Asthma Allergy. 2021 Feb 11;14:127-134. doi: 10.2147/JAA.S290424. eCollection 2021.
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