Harvey Richard J, Goddard John C, Wise Sarah K, Schlosser Rodney J
Department of Otolaryngology-Head and Neck Surgery, Medical University of South Carolina, Charleston, SC, USA.
Otolaryngol Head Neck Surg. 2008 Jul;139(1):137-42. doi: 10.1016/j.otohns.2008.04.020.
Assess paranasal sinus distribution of topical solutions following endoscopic sinus surgery (ESS) using various delivery devices.
Experimental prospective study.
Ten cadaver sinus systems were irrigated with Gastroview before surgery, after ESS, and after medial maxillectomy. Delivery was via pressurized spray (NasaMist), neti pot (NasaFlo), and squeeze bottle (Sinus Rinse). Scans were performed before and after each delivery with a portable CT machine (Xoran xCAT), and blinded assessments were made for distribution to individual sinuses.
Total sinus distribution was greater post-ESS (P < 0.001). Additional distribution was gained with medial maxillectomy (P = 0.02). Influence of delivery device on distribution was significantly higher with neti pot > squeeze bottle > pressurized spray (P < 0.001). Frontal sinus penetration was greatest after surgery (P = 0.001).
ESS greatly enhances the delivery of nasal solutions, regardless of delivery device. Pressurized spray solutions in un-operated sinuses provide little more than nasal cavity distribution. Use of squeeze bottle/neti pot post-ESS offers a greatly enhanced ability to deliver solutions to the paranasal sinuses.
使用各种给药装置评估鼻内镜鼻窦手术(ESS)后局部溶液在鼻窦中的分布情况。
实验性前瞻性研究。
对10个尸体鼻窦系统在手术前、ESS后以及上颌骨内侧切除术后用胃肠透视剂进行冲洗。给药方式为加压喷雾(NasaMist)、鼻壶(NasaFlo)和挤压瓶(鼻窦冲洗器)。每次给药前后使用便携式CT机(Xoran xCAT)进行扫描,并对各个鼻窦的分布情况进行盲法评估。
ESS后鼻窦的总体分布情况更佳(P < 0.001)。上颌骨内侧切除术后分布进一步增加(P = 0.02)。给药装置对分布的影响,鼻壶 > 挤压瓶 > 加压喷雾,差异有统计学意义(P < 0.001)。手术后额窦的渗透情况最佳(P = 0.001)。
ESS极大地增强了鼻腔溶液的给药效果,无论使用何种给药装置。未手术鼻窦中的加压喷雾溶液仅能在鼻腔内分布。ESS后使用挤压瓶/鼻壶可大大增强将溶液输送至鼻窦的能力。