Miller I J, Suthanthiran M, Riggio R R, Williams J J, Riehle R A, Vaughan E D, Stubenbord W T, Mouradian J, Cheigh J S, Stenzel K H
Am J Med. 1985 Aug;79(2):201-8. doi: 10.1016/0002-9343(85)90010-5.
Forty-six renal donors who responded to a questionnaire and two additional donors with nephrotic syndrome and renal insufficiency were studied. The mean age was 46 +/- 2.0 years (mean +/- SE). Duration of follow-up was 6 +/- 0.5 years. Serum creatinine levels increased from 1.0 +/- 0.03 mg/dl before donation to 1.2 +/- 0.04 mg/dl at follow-up. The incidence of proteinuria (more than 150 mg over 24 hours) was 39 percent. The serum creatinine level was 1.0 +/- 0.08 mg/dl and 1.2 +/- 0.06 mg/dl in the proteinuric and nonproteinuric groups, respectively. The incidence of hypertension was 31 percent with a serum creatinine level of 1.1 +/- 0.11 mg/dl and 1.2 +/- 0.07 mg/dl in the hypertensive and normotensive groups, respectively. One patient with nephrotic syndrome had proliferative glomerulonephritis. It is concluded that renal donation is associated with a minimal but statistically significant increment in serum creatinine levels. The incidence of mild hypertension and proteinuria is increased, but impact on renal function is minimal as assessed by serum creatinine determination.
对46名回复问卷的肾供体以及另外两名患有肾病综合征和肾功能不全的供体进行了研究。平均年龄为46±2.0岁（均值±标准误）。随访时间为6±0.5年。血清肌酐水平从捐献前的1.0±0.03mg/dl升至随访时的1.2±0.04mg/dl。蛋白尿（24小时超过150mg）的发生率为39%。蛋白尿组和无蛋白尿组的血清肌酐水平分别为1.0±0.08mg/dl和1.2±0.06mg/dl。高血压的发生率为31%，高血压组和血压正常组的血清肌酐水平分别为1.1±0.11mg/dl和1.2±0.07mg/dl。一名患有肾病综合征的患者患有增殖性肾小球肾炎。得出的结论是，肾捐献与血清肌酐水平的微小但具有统计学意义的升高有关。轻度高血压和蛋白尿的发生率增加，但通过血清肌酐测定评估，对肾功能的影响很小。
