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人参皂苷 Rb1 可减轻链脲佐菌素诱导的糖尿病大鼠心脏中 RyR2 的氧化/羰基应激损伤和功能障碍。

Ginsenoside Rb1 reduces oxidative/carbonyl stress damage and dysfunction of RyR2 in the heart of streptozotocin-induced diabetic rats.

机构信息

Guang'anmen Hospital of China Academy of Chinese Medical Sciences, No 5. Beixiange Street, Beijing, 100053, China.

International Campus, Zhejiang University-University of Edinburgh Institute, Zhejiang University, Haining, China.

出版信息

BMC Cardiovasc Disord. 2024 Jul 3;24(1):333. doi: 10.1186/s12872-024-04005-8.

DOI:10.1186/s12872-024-04005-8
PMID:38961333
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11221176/
Abstract

BACKGROUND: Oxidative stress may contribute to cardiac ryanodine receptor (RyR2) dysfunction in diabetic cardiomyopathy. Ginsenoside Rb1 (Rb1) is a major pharmacologically active component of ginseng to treat cardiovascular diseases. Whether Rb1 treat diabetes injured heart remains unknown. This study was to investigate the effect of Rb1 on diabetes injured cardiac muscle tissue and to further investigate its possible molecular pharmacology mechanisms. METHODS: Male Sprague-Dawley rats were injected streptozotocin solution for 2 weeks, followed 6 weeks Rb1 or insulin treatment. The activity of SOD, CAT, Gpx, and the levels of MDA was measured; histological and ultrastructure analyses, RyR2 activity and phosphorylated RyR2(Ser2808) protein expression analyses; and Tunel assay were performed. RESULTS: There was decreased activity of SOD, CAT, Gpx and increased levels of MDA in the diabetic group from control. Rb1 treatment increased activity of SOD, CAT, Gpx and decreased the levels of MDA as compared with diabetic rats. Neutralizing the RyR2 activity significantly decreased in diabetes from control, and increased in Rb1 treatment group from diabetic group. The expression of phosphorylation of RyR2 Ser2808 was increased in diabetic rats from control, and were attenuated with insulin and Rb1 treatment. Diabetes increased the apoptosis rate, and Rb1 treatment decreased the apoptosis rate. Rb1 and insulin ameliorated myocardial injury in diabetic rats. CONCLUSIONS: These data indicate that Rb1 could be useful for mitigating oxidative damage, reduced phosphorylation of RyR2 Ser2808 and decreased the apoptosis rate of cardiomyocytes in diabetic cardiomyopathy.

摘要

背景：氧化应激可能导致糖尿病心肌病中心肌兰尼碱受体（RyR2）功能障碍。人参皂苷 Rb1（Rb1）是治疗心血管疾病的人参主要药效活性成分之一。Rb1 是否治疗糖尿病损伤的心脏尚不清楚。本研究旨在探讨 Rb1 对糖尿病损伤心肌组织的影响，并进一步探讨其可能的分子药理学机制。

方法：雄性 Sprague-Dawley 大鼠连续 2 周注射链脲佐菌素溶液，随后给予 Rb1 或胰岛素治疗 6 周。测定 SOD、CAT、Gpx 的活性和 MDA 的水平；进行组织学和超微结构分析、RyR2 活性和磷酸化 RyR2（Ser2808）蛋白表达分析；以及 TUNEL 检测。

结果：糖尿病组 SOD、CAT、Gpx 活性降低，MDA 水平升高。与糖尿病组相比，Rb1 治疗组 SOD、CAT、Gpx 活性升高，MDA 水平降低。与对照组相比，糖尿病组 RyR2 活性降低，磷酸化 RyR2 Ser2808 蛋白表达增加，而 Rb1 治疗组 RyR2 活性增加。糖尿病大鼠的凋亡率增加，Rb1 治疗组的凋亡率降低。Rb1 和胰岛素改善了糖尿病大鼠的心肌损伤。

结论：这些数据表明，Rb1 可减轻糖尿病心肌病中的氧化损伤，降低 RyR2 Ser2808 的磷酸化水平，减少心肌细胞的凋亡率。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/510f/11221176/764424f0fb78/12872_2024_4005_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/510f/11221176/47b7765efe3d/12872_2024_4005_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/510f/11221176/b655cb3ea649/12872_2024_4005_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/510f/11221176/0d850bdbf5cc/12872_2024_4005_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/510f/11221176/0c38ffe505cf/12872_2024_4005_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/510f/11221176/9f638235535a/12872_2024_4005_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/510f/11221176/fa84538adc4d/12872_2024_4005_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/510f/11221176/6ffa939bfa9c/12872_2024_4005_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/510f/11221176/764424f0fb78/12872_2024_4005_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/510f/11221176/47b7765efe3d/12872_2024_4005_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/510f/11221176/b655cb3ea649/12872_2024_4005_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/510f/11221176/0d850bdbf5cc/12872_2024_4005_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/510f/11221176/0c38ffe505cf/12872_2024_4005_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/510f/11221176/9f638235535a/12872_2024_4005_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/510f/11221176/fa84538adc4d/12872_2024_4005_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/510f/11221176/6ffa939bfa9c/12872_2024_4005_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/510f/11221176/764424f0fb78/12872_2024_4005_Fig8_HTML.jpg

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[4]
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本文引用的文献

[1]
Mouse models of diabetes-related ulcers: a systematic review and network meta-analysis.

EBioMedicine. 2023-12

[2]
Chrysin-based supramolecular cyclodextrin-calixarene drug delivery system: a novel approach for attenuating cardiac fibrosis in chronic diabetes.

Front Pharmacol. 2023-12-18

[3]
The role of ferroptosis in diabetic cardiovascular diseases and the intervention of active ingredients of traditional Chinese medicine.

Front Pharmacol. 2023-10-26

[4]
Cardiovascular protective effect of sodium-glucose cotransporter 2 inhibitors on patients with acute coronary syndrome and type 2 diabetes mellitus: a retrospective study.

BMC Cardiovasc Disord. 2023-10-7

[5]
Gut microbiota in the pathogenesis and therapeutic approaches of diabetes.

EBioMedicine. 2023-11

[6]
Alterations of hepatic energy metabolism in murine models of obesity, diabetes and fatty liver diseases.

EBioMedicine. 2023-8

[7]
A genetically supported drug repurposing pipeline for diabetes treatment using electronic health records.

EBioMedicine. 2023-8

[8]
Reprogramming astrocytic NDRG2/NF-κB/C3 signaling restores the diabetes-associated cognitive dysfunction.

EBioMedicine. 2023-7

[9]
Diets, Gut Microbiota and Metabolites.

Phenomics. 2023-3-2

[10]
Elevated markers of DNA damage and senescence are associated with the progression of albuminuria and restrictive lung disease in patients with type 2 diabetes.

EBioMedicine. 2023-4

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