Koff W C, Fidler I J
Antiviral Res. 1985 Jun;5(3):179-90. doi: 10.1016/0166-3542(85)90050-6.
The natural targeting of liposomes to cells of the reticuloendothelial system should be exploited to examine whether selective delivery of antiviral or immunomodulatory agents could be beneficial for the treatment of virus diseases. In this review we discuss the potential use of liposomes in the treatment of virus diseases, the targeting of liposome-encapsulated immunomodulators to macrophages in order to render these cells cytolytic for virus-infected cells, and the targeting of liposome-encapsulated antiviral drugs to macrophages to achieve direct suppression of virus replication with in these cells.
应利用脂质体对网状内皮系统细胞的天然靶向性，来研究抗病毒或免疫调节药物的选择性递送是否有利于病毒疾病的治疗。在这篇综述中，我们讨论了脂质体在病毒疾病治疗中的潜在用途、将脂质体包裹的免疫调节剂靶向巨噬细胞以使这些细胞对病毒感染细胞具有细胞溶解作用，以及将脂质体包裹的抗病毒药物靶向巨噬细胞以在这些细胞内直接抑制病毒复制。
