mDIXON-Quant 技术对男性成人群体骨密度评估的诊断准确性。

mDIXON-Quant technique diagnostic accuracy for assessing bone mineral density in male adult population.

机构信息

Department of Radiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Middle Yanchang Road, Shanghai, 200072, China.

出版信息

BMC Musculoskelet Disord. 2023 Feb 14;24(1):125. doi: 10.1186/s12891-023-06225-z.

BACKGROUND

To investigate the diagnostic efficacy of mDIXON-Quant technique for prediction of bone loss in male adults.

METHODS

One hundred thirty-eight male adults were divided into normal, osteopenia, and osteoporosis groups based on DXA and QCT for the lumbar spine. Differences in mDIXON-Quant parameters [fat fraction (FF) and T2 value] among three groups, as well as the correlation of mDIXON-Quant parameters and bone mineral density (BMD) were analyzed. The areas under the curves (AUCs) for mDIXON-Quant parameters for prediction of low bone mass were calculated.

RESULTS

According to DXA standard, FF and T2 value were significantly increased in osteoporosis group compared with normal group (P = 0.012 and P < 0.001). According to QCT standard, FF was significantly increased in osteopenia and osteoporosis groups compared with normal group (both P < 0.001). T2 values were significantly different among three groups (all P < 0.05). After correction for age and body mass index, FF was negatively correlated with areal BMD and volumetric BMD (r = -0.205 and -0.604, respectively; both P < 0.05), and so was T2 value (r = -0.324 and -0.444, respectively; both P < 0.05). The AUCs for predicting low bone mass according to DXA and QCT standards were 0.642 and 0.898 for FF, 0.648 and 0.740 for T2 value, and 0.677 and 0.920 for both combined, respectively.

CONCLUSIONS

FF combined with T2 value has a better diagnostic efficacy than FF or T2 value alone in prediction of low bone mass in male adults, which is expected to be a promising MRI method for the screening of bone quality.

TRIAL REGISTRATION

ChiCTR1900024511 (Registered 13-07-2019).

背景

探讨 mDIXON-Quant 技术对男性成年人骨量丢失预测的诊断效能。

方法

根据 DXA 和 QCT 腰椎骨密度将 138 例男性成年人分为正常、骨量减少和骨质疏松组。分析三组间 mDIXON-Quant 参数（脂肪分数[FF]和 T2 值）的差异，以及 mDIXON-Quant 参数与骨密度（BMD）的相关性。计算 mDIXON-Quant 参数预测低骨量的曲线下面积（AUC）。

结果

根据 DXA 标准，与正常组相比，骨质疏松组 FF 和 T2 值显著升高（P=0.012 和 P<0.001）。根据 QCT 标准，与正常组相比，骨量减少组和骨质疏松组 FF 均显著升高（均 P<0.001）。三组 T2 值差异均有统计学意义（均 P<0.05）。校正年龄和体重指数后，FF 与面积 BMD 和体积 BMD 呈负相关（r=-0.205 和-0.604，均 P<0.05），T2 值也呈负相关（r=-0.324 和-0.444，均 P<0.05）。根据 DXA 和 QCT 标准预测低骨量的 AUC 分别为 FF 的 0.642 和 0.898、T2 值的 0.648 和 0.740、两者联合的 0.677 和 0.920。