Factors affecting the metabolic control of cytosolic and lysosomal glycogen levels in the liver.

Rats with a gentic deficiency of phosphorylase kinase have been treated with the 1,4-alpha-glucosidase inhibitor, Acarbose. Lysosomal glycogen metabolism has been markedly altered and the results support the concept of a feedback control mechanism operating on the uptake mechanism into the lysosomal compartment.