Calder P C, Geddes R
Department of Biochemistry, University of Auckland, New Zealand.
Carbohydr Res. 1989 Aug 1;191(1):71-8. doi: 10.1016/0008-6215(89)85047-5.
Intraperitoneal injections (approximately 400 mg/kg of body weight) of acarbose, an inhibitor of acid (1----4)-alpha-D-glucosidase, perturb the metabolism of glycogen in the liver, resulting in excess storage of lysosomal glycogen. The metabolism of skeletal muscle glycogen was unaffected, suggesting that acarbose either does not enter the tissue or that the muscle alpha-D-glucosidase is not inhibited. The hydrolysis of maltose and glycogen by the acid alpha-D-glucosidases from rat liver, rat skeletal muscle, and human placenta was inhibited competitively by acarbose. Thus, the lack of effect of acarbose upon the metabolism of muscle glycogen is due to its inability to enter the tissue.
腹腔注射（约400毫克/千克体重）阿卡波糖，一种酸性（1----4）-α-D-葡萄糖苷酶抑制剂，会扰乱肝脏中糖原的代谢，导致溶酶体糖原过度储存。骨骼肌糖原的代谢未受影响，这表明阿卡波糖要么不进入该组织，要么肌肉中的α-D-葡萄糖苷酶未被抑制。来自大鼠肝脏、大鼠骨骼肌和人胎盘的酸性α-D-葡萄糖苷酶对麦芽糖和糖原的水解受到阿卡波糖的竞争性抑制。因此，阿卡波糖对肌肉糖原代谢缺乏影响是由于其无法进入该组织。
