Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Industrial Pharmacy Department, Faculty of Pharmacy, Assiut University, Assiut, Egypt.
Drug Dev Ind Pharm. 2024 Jul;50(7):605-618. doi: 10.1080/03639045.2024.2376624. Epub 2024 Jul 11.
Obesity has become a prevalent issue worldwide, leading to various complications such as hyperlipidemia, diabetes, and cardiovascular problems. Statins, as FDA approved anti-hyperlipidemic drugs, still pose some concerns upon their administration. Recently, researchers have looked for natural products as an alternative to manage hyperlipidemia and obesity.
This work aimed to study the hypolipidemic effect of garden cress (GC) from different preparations; orally administered seeds, and hydrogel, in comparison to atorvastatin.
GC hydrogel was prepared from the GC aqueous extract and pharmaceutically evaluated for its pH, spreadability, seeds content, homogeneity, rheology, and release. The rat's body weight, blood glucose levels, total lipid profile, and liver biomarkers were evaluated on obese rats for one month. In addition, the histopathology study was also performed.
GC hydrogel had acceptable pharmaceutical properties and showed a sustained release performance over 24 h. Oral and topical GC significantly reduced the lipid profiles, blood sugar and ALT, AST levels more than the negative control group and comparable to atorvastatin. It was found that oral GC showed a significant effect on the percentage decrease in the rat's body weight than the applied hydrogel. Histopathology study revealed a better outcome in the histological structure of pancreas and liver compared with rats feed on high fat diet post-treatment for one month.
GC orally administered, or topically applied hydrogel could be a promising, safe alternative formulation to atorvastatin in managing hyperlipidemia and normalizing body weight of obese rats.
肥胖已成为全球普遍存在的问题,导致高血脂、糖尿病和心血管问题等各种并发症。他汀类药物作为 FDA 批准的抗高血脂药物,在使用时仍存在一些问题。最近,研究人员一直在寻找天然产物作为管理高血脂和肥胖的替代方法。
本研究旨在研究不同制剂的荠菜(GC)的降血脂作用,包括口服种子和水凝胶,与阿托伐他汀进行比较。
从 GC 水提物中制备 GC 水凝胶,并对其 pH 值、铺展性、种子含量、均匀性、流变学和释放进行了药学评价。在肥胖大鼠身上进行了一个月的实验,评估了 GC 水凝胶对大鼠体重、血糖水平、总脂质谱和肝生物标志物的影响。此外,还进行了组织病理学研究。
GC 水凝胶具有可接受的药学性质,在 24 小时内表现出持续释放性能。口服和局部 GC 显著降低了血脂谱、血糖和 ALT、AST 水平,效果优于阴性对照组,与阿托伐他汀相当。结果发现,口服 GC 对大鼠体重的降低百分比有显著影响,优于应用水凝胶。组织病理学研究显示,与高脂饮食喂养一个月后的大鼠相比,胰腺和肝脏的组织学结构有更好的改善。
口服 GC 或局部应用水凝胶可能是一种有前途的、安全的替代阿托伐他汀的方法,可用于治疗高血脂和肥胖大鼠的体重。