Guizhou Medical University, Guiyang, Guizhou 550004, China; Department of Urology, Guizhou Provincial People's Hospital, Guiyang, Guizhou 550002, China.
Department of Urology, Guizhou Provincial People's Hospital, Guiyang, Guizhou 550002, China.
Tissue Cell. 2024 Aug;89:102453. doi: 10.1016/j.tice.2024.102453. Epub 2024 Jun 18.
Baicalin is a flavonoid derived from the root of the medicinal plant Scutellaria baicalensis Georgi (S. baicalensis) and is known for its various pharmacological properties. This study aimed to investigate the impact of baicalin (BAI) on the occurrence of kidney calcium oxalate crystal formation induced by ethylene glycol in male SD rats.
A rat model of renal stones was created and various concentrations of baicalin were used for intervention. Samples of urine, blood, and kidney tissue were taken from the rats, and they were euthanized for biochemical and histopathological examinations.
Our results show that baicalin treatment improved the weight loss induced by ethylene glycol (EG) and ammonium chloride (AC) in rats. Baicalin also reduced the formation of calcium oxalate crystals and protected kidney function in rats with urolithiasis. Furthermore, it lowered the level of malondialdehyde (MDA) and elevated the activity of antioxidant enzymes compared to the stone control group. Additionally, baicalin notably alleviated renal inflammation in rats with urolithiasis.
The present study attributed clinical evidence first time that claiming the significant antiurolithic effect of baicalin and could be a cost-effective candidate for the prevention and treatment of urolithiasis.
黄芩苷是一种来源于药用植物黄芩（Scutellaria baicalensis Georgi）根的黄酮类化合物，具有多种药理学特性。本研究旨在探讨黄芩苷（BAI）对乙二醇诱导的雄性 SD 大鼠肾脏草酸钙晶体形成的影响。
建立了大鼠肾结石模型，并对不同浓度的黄芩苷进行了干预。从大鼠中采集尿液、血液和肾脏组织样本，并对其进行安乐死，进行生化和组织病理学检查。
我们的结果表明，黄芩苷治疗可改善乙二醇（EG）和氯化铵（AC）诱导的大鼠体重减轻。黄芩苷还减少了肾结石大鼠草酸钙晶体的形成，并保护了肾功能。此外，与结石对照组相比，它降低了丙二醛（MDA）的水平，提高了抗氧化酶的活性。此外，黄芩苷显著减轻了肾结石大鼠的肾脏炎症。
本研究首次提供了黄芩苷具有显著抗结石作用的临床证据，可能是预防和治疗结石病的一种具有成本效益的候选药物。
