S.L.T. Institute of Pharmaceutical Sciences, Guru Ghasidas University, Bilapur, India.
UIPS, Panjab University, Chandigarh, India.
Chin J Nat Med. 2013 Sep;11(5):466-71. doi: 10.1016/S1875-5364(13)60085-0.
Cystone is an approved Ayurvedic polyherbal proprietary medicine used in India for various urinary disorders, including urolithiasis.
To evaluate the protective effect of Cystone against hyperoxaluria-induced oxidative stress and calcium oxalate crystal deposition in urolithiasis.
Ethylene glycol (EG) (0.75%, V/V) in drinking water was given to rats for 28 days to induce urolithiasis with simultaneous treatment of Cystone (500 and 750 mg/kg body weight), and various urinary risk factors of urolithiasis and antioxidant markers were assessed.
EG treatment lead to increased urine volume and lowered urinary pH, along with increased urinary excretion of oxalate, calcium and phosphate in untreated animals. These changes caused extensive calcium oxalate crystal deposition, increased lipid peroxidation and decreased activity of antioxidant enzymes (SOD, catalase and GPx) in the kidney of untreated rats. Cystone prevented these hyperoxaluric manifestations and inhibited calcium oxalate crystal deposition in treated rats at both doses.
Cystone therapy provides protection against hyperoxaluria-induced oxidative stress and calcium oxalate crystal deposition by improving renal tissue antioxidant status and diuresis.
Cystone 是一种在印度被批准用于治疗各种泌尿系统疾病（包括尿路结石）的阿育吠陀草药复方专利药物。
评估 Cystone 对草酸过多引起的氧化应激和尿路结石中草酸钙晶体沉积的保护作用。
用乙二醇（EG）（0.75%，V/V）在饮用水中给大鼠处理 28 天，诱导形成尿路结石，并同时用 Cystone（500 和 750 mg/kg 体重）进行治疗，评估各种尿路结石的风险因素和抗氧化标志物。
EG 处理导致未处理动物的尿量增加和尿液 pH 值降低，同时尿液中草酸盐、钙和磷酸盐的排泄增加。这些变化导致未处理大鼠肾脏中广泛的草酸钙晶体沉积、脂质过氧化增加和抗氧化酶（SOD、过氧化氢酶和 GPx）活性降低。Cystone 在两种剂量下都能预防这些高草酸尿表现，并抑制治疗大鼠的草酸钙晶体沉积。
Cystone 治疗通过改善肾脏组织的抗氧化状态和利尿作用，为对抗高草酸尿引起的氧化应激和草酸钙晶体沉积提供了保护。
