Valenzise M, Bombaci B, Lombardo F, Passanisi S, Lombardo C, Lugarà C, D'Amico F, Grasso L, Aguennouz M, Catalano A, Salzano G
Department of Human Pathology in Adult and Developmental Age "Gaetano Barresi", University of Messina, Messina, Italy.
Department of Biomedical Sciences and Morphological and Functional Imaging, University of Messina, Messina, Italy.
J Endocrinol Invest. 2025 Jan;48(1):227-232. doi: 10.1007/s40618-024-02414-2. Epub 2024 Jul 4.
This pivotal study aimed to evaluate circulating levels of bone remodeling markers in children and adolescents at the onset of type 1 diabetes (T1D). Additionally, we assessed their correlation with glucose control, residual β-cell function, and the severity of presentation.
In this single-center cross-sectional study, we recruited children and adolescents newly diagnosed with T1D at our tertiary-care Diabetes Centre. Anamnestic, anthropometric, clinical, and biochemical data at T1D diagnosis were collected. Basal and stimulated C-peptide levels were assessed, along with the following bone remodeling biomarkers: osteocalcin (OC), alkaline phosphatase (ALP), parathormone (PTH), 25-OH Vitamin D (25OH-D), and the C-terminal cross-linked telopeptide of type 1 collagen (CTX).
We enrolled 29 individuals newly diagnosed with T1D, with a slight male prevalence (51.7%). The mean age was 8.4 ± 3.7 years. A positive correlation between OC and stimulated C-peptide (R = 0.538; p = 0.026) and between PTH and serum HCO3- (R = 0.544; p = 0.025) was found. No other correlations between bone remodeling biomarkers and clinical variables were detected.
Our data showed a positive correlation between OC levels and residual β-cell function in children and adolescents at T1D presentation. Further longitudinal studies evaluating OC levels in pediatric subjects with T1D are needed to better understand the complex interaction between bone and glucose metabolisms.
这项关键研究旨在评估1型糖尿病（T1D）发病时儿童和青少年骨重塑标志物的循环水平。此外，我们评估了它们与血糖控制、残余β细胞功能及发病严重程度的相关性。
在这项单中心横断面研究中，我们在三级医疗糖尿病中心招募了新诊断为T1D的儿童和青少年。收集了T1D诊断时的既往史、人体测量学、临床和生化数据。评估了基础和刺激后的C肽水平，以及以下骨重塑生物标志物：骨钙素（OC）、碱性磷酸酶（ALP）、甲状旁腺激素（PTH）、25-羟基维生素D（25OH-D）和1型胶原C端交联肽（CTX）。
我们纳入了29例新诊断为T1D的个体，男性略占优势（51.7%）。平均年龄为8.4±3.7岁。发现OC与刺激后的C肽之间呈正相关（R = 0.538；p = 0.026），PTH与血清HCO3-之间呈正相关（R = 0.544；p = 0.025）。未检测到骨重塑生物标志物与临床变量之间的其他相关性。
我们的数据显示，在T1D发病时，儿童和青少年的OC水平与残余β细胞功能之间呈正相关。需要进一步开展纵向研究，评估T1D儿科患者的OC水平，以更好地理解骨骼与葡萄糖代谢之间的复杂相互作用。
