Department of Pediatrics, University of Arkansas for Medical Sciences and Arkansas Children's Hospital Research Institute, Little Rock, AR 72205, USA.
Osteoporos Int. 2012 Jun;23(6):1799-806. doi: 10.1007/s00198-011-1807-7. Epub 2011 Nov 9.
To determine whether undercarboxylated osteocalcin (UC-OC) or gamma-carboxyglutamic-carboxylated-type osteocalcin (GLA-OC) concentrations deviate from normal in type 1 diabetes (T1D), serum levels were compared between 115 subjects with T1D and 55 age-matched healthy controls. UC-OC and GLA-OC concentrations were similar between groups; however, in T1D, UC-OC correlated positively with markers of insulin exposure, either endogenously produced or exogenously administered.
A study was conducted to determine whether dysregulation of circulating concentrations of UC-OC or GLA-OC occurs in patients with type 1 diabetes, a condition of insulin deficiency without insulin resistance.
We measured serum concentrations of UC-OC and GLA-OC in 115 subjects with T1D, ages 14-40 years, and in 55 age-matched healthy control subjects. Relationships between UC-OC and GLA-OC concentrations and patient characteristics (gender and age), indices of glycemic control (hemoglobin A1c (HbA1c), fasting plasma glucose, C-peptide concentration, 3-day average glucose measured by a continuous glucose sensor, total daily insulin dose) and circulating indices of skeletal homeostasis (total calcium, 25-OH vitamin D, parathyroid hormone, insulin-like growth factor 1 (IGF-1), type 1 collagen degradation fragments (CTX), adiponectin, leptin) were examined. Between group differences in the concentrations of UC-OC and GLA-OC were the main outcome measures.
Although adiponectin levels were higher in the T1D group, between-group comparisons did not reveal statistically significant differences in concentration of UC-OC, GLA-OC, CTX or leptin between the T1D and control populations. Instead, by multivariate regression modeling, UC-OC was correlated with younger age (p < 0.001), higher CTX (p < 0.001), lower HbA1c (p = 0.013), and higher IGF-1 (p = 0.086). Moreover, within the T1D subgroup, UC-OC was positively correlated with C-peptide/glucose ratio (reflecting endogenous insulin secretion), with IGF-1 (reflecting intra-portal insulin sufficiency), and with total daily insulin dose.
In T1D, UC-OC appears to correlate positively with markers of insulin exposure, either endogenously produced or exogenously administered.
确定在 1 型糖尿病（T1D）患者中，是否存在非羧化骨钙素（UC-OC）或 γ-羧基谷氨酸羧化型骨钙素（GLA-OC）浓度偏离正常的情况，为此比较了 115 例 T1D 患者和 55 例年龄匹配的健康对照者的血清水平。
我们测量了 115 例年龄 14-40 岁的 T1D 患者和 55 例年龄匹配的健康对照者的血清 UC-OC 和 GLA-OC 浓度。UC-OC 和 GLA-OC 浓度与患者特征（性别和年龄）、血糖控制指标（糖化血红蛋白（HbA1c）、空腹血糖、C 肽浓度、连续血糖传感器测量的 3 天平均血糖、总每日胰岛素剂量）和循环骨骼稳态指标（总钙、25-羟维生素 D、甲状旁腺激素、胰岛素样生长因子 1（IGF-1）、1 型胶原降解片段（CTX）、脂联素、瘦素）之间的关系进行了研究。主要观察指标为两组间 UC-OC 和 GLA-OC 浓度的差异。
尽管 T1D 组的脂联素水平较高，但两组间比较显示，T1D 组和对照组的 UC-OC、GLA-OC、CTX 或瘦素浓度无统计学差异。相反，通过多元回归模型，UC-OC 与年龄较小（p<0.001）、CTX 较低（p<0.001）、HbA1c 较高（p=0.013）和 IGF-1 较高（p=0.086）相关。此外，在 T1D 亚组中，UC-OC 与 C 肽/血糖比值（反映内源性胰岛素分泌）、IGF-1（反映门静脉内胰岛素充足度）和总每日胰岛素剂量呈正相关。
在 T1D 中，UC-OC 似乎与内源性或外源性产生的胰岛素暴露标志物呈正相关。
