Stewart I A, Guy A M, Allison R S, Thomson N J
Clin Otolaryngol Allied Sci. 1985 Jun;10(3):145-9. doi: 10.1111/j.1365-2273.1985.tb01183.x.
In a double blind randomised trial of 95 children aged 3-8 years with otitis media with effusion (OME), the efficacy of the mucolytic agent bromhexine hydrochloride (Bisolvon) was compared with a placebo. Each child received two 4 week courses of either bromhexine or placebo in a random fashion. One hundred and ninety ears were available for analysis, i.e. 380 'ear treatments'. There were 198 ears in the placebo group and 182 ears in the bromhexine group. The resolution rate in the placebo treated group was 19% and in the bromhexine treated group 16%. Bromhexine does not appear to be a useful drug for the treatment of OME in children.
在一项针对95名3至8岁患有中耳积液（OME）儿童的双盲随机试验中，将黏液溶解剂盐酸溴己新（必嗽平）与安慰剂的疗效进行了比较。每个孩子以随机方式接受两个为期4周的溴己新或安慰剂疗程。共有190只耳朵可供分析，即380次“耳部治疗”。安慰剂组有198只耳朵，溴己新组有182只耳朵。安慰剂治疗组的治愈率为19%，溴己新治疗组为16%。溴己新似乎不是治疗儿童中耳积液的有效药物。
