Manenti Rosa, Baglio Francesca, Pagnoni Ilaria, Gobbi Elena, Campana Elena, Alaimo Cristina, Rossetto Federica, Di Tella Sonia, Pagliari Chiara, Geviti Andrea, Bonfiglio Natale Salvatore, Calabrò Rocco Salvatore, Cimino Vincenzo, Binetti Giuliano, Quartarone Angelo, Bramanti Placido, Cappa Stefano F, Rossini Paolo Maria, Cotelli Maria
Neuropsychology Unit, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.
IRCCS Fondazione Don Carlo Gnocchi - ONLUS, Milan, Italy.
Front Aging Neurosci. 2024 Jun 18;16:1414593. doi: 10.3389/fnagi.2024.1414593. eCollection 2024.
In recent years, an increasing number of studies have examined the potential efficacy of cognitive training procedures in individuals with normal ageing and mild cognitive impairment (MCI).
The aims of this study were to (i) evaluate the efficacy of the cognitive Virtual Reality Rehabilitation System (VRRS) combined with anodal transcranial direct current stimulation (tDCS) applied to the left dorsolateral prefrontal cortex compared to placebo tDCS stimulation combined with VRRS and (ii) to determine how to prolong the beneficial effects of the treatment. A total of 109 subjects with MCI were assigned to 1 of 5 study groups in a randomized controlled trial design: (a) face-to-face (FTF) VRRS during anodal tDCS followed by cognitive telerehabilitation (TR) (clinic-atDCS-VRRS+Tele@H-VRRS); (b) FTF VRRS during placebo tDCS followed by TR (clinic-ptDCS-VRRS+Tele@H-VRRS); (c) FTF VRRS followed by cognitive TR (clinic-VRRS+Tele@H-VRRS); (d) FTF VRRS followed by at-home unstructured cognitive stimulation (clinic-VRRS+@H-UCS); and (e) FTF cognitive treatment as usual (clinic-TAU).
An improvement in episodic memory was observed after the end of clinic-atDCS-VRRS ( < 0.001). We found no enhancement in episodic memory after clinic-ptDCS-VRRS or after clinic-TAU.Moreover, the combined treatment led to prolonged beneficial effects (clinic-atDCS-VRRS+Tele@H-VRRS vs. clinic-ptDCS-VRRS+Tele@H-VRRS: = 0.047; clinic-atDCS-VRRS+Tele@H-VRRS vs. clinic-VRRS+Tele@H-VRRS: = 0.06).
The present study provides preliminary evidence supporting the use of individualized VRRS combined with anodal tDCS and cognitive telerehabilitation for cognitive rehabilitation.
https://clinicaltrials.gov/study/NCT03486704?term=NCT03486704&rank=1, NCT03486704.
近年来，越来越多的研究探讨了认知训练程序对正常衰老和轻度认知障碍（MCI）个体的潜在疗效。
本研究的目的是：（i）评估认知虚拟现实康复系统（VRRS）联合阳极经颅直流电刺激（tDCS）应用于左侧背外侧前额叶皮层与安慰剂tDCS刺激联合VRRS相比的疗效；（ii）确定如何延长治疗的有益效果。在一项随机对照试验设计中，将109名MCI受试者分配到5个研究组中的1个：（a）阳极tDCS期间的面对面（FTF）VRRS，随后进行认知远程康复（TR）（门诊阳极tDCS-VRRS+远程@家-VRRS）；（b）安慰剂tDCS期间的FTF VRRS，随后进行TR（门诊安慰剂tDCS-VRRS+远程@家-VRRS）；（c）FTF VRRS，随后进行认知TR（门诊-VRRS+远程@家-VRRS）；（d）FTF VRRS，随后进行在家非结构化认知刺激（门诊-VRRS+在家-UCS）；以及（e）常规的FTF认知治疗（门诊-常规治疗）。
门诊阳极tDCS-VRRS结束后，情景记忆有所改善（<0.001）。我们发现在门诊安慰剂tDCS-VRRS后或门诊常规治疗后情景记忆没有增强。此外，联合治疗导致有益效果延长（门诊阳极tDCS-VRRS+远程@家-VRRS与门诊安慰剂tDCS-VRRS+远程@家-VRRS相比：=0.047；门诊阳极tDCS-VRRS+远程@家-VRRS与门诊-VRRS+远程@家-VRRS相比：=0.06）。
本研究提供了初步证据，支持使用个性化VRRS联合阳极tDCS和认知远程康复进行认知康复。
https://clinicaltrials.gov/study/NCT03486704?term=NCT03486704&rank=1，NCT03486704。
