Liu Yuan, Yuan Hui, Fan JingJia, Wang Han, Xie HuiYu, Wan JunFeng, Hu XueYing, Zhou Jie, Liu Liang
Department of Clinical Medicine, School of Clinical Medical, Southwest Medical University, Luzhou, 646000, Sichuan, China.
Dept Neurosurg, Affiliated Hosp, Southwest Med Univ, Luzhou, 646000, People's Republic of China.
Discov Oncol. 2024 Jul 5;15(1):266. doi: 10.1007/s12672-024-01144-4.
Glioma is the most common malignant tumor in the central nervous system, and its unique pathogenesis often leads to poor treatment outcomes and prognosis. In 2021, the World Health Organization (WHO) divided gliomas into five categories based on their histological characteristics and molecular changes. Non-coding RNA is a type of RNA that does not encode proteins but can exert biological functions at the RNA level, and long non-coding RNA (lncRNA) is a type of non-coding RNA with a length exceeding 200 nt. It is controlled by various transcription factors and plays an indispensable role in the regulatory processes in various cells. Numerous studies have confirmed that the dysregulation of lncRNA is critical in the pathogenesis, progression, and malignancy of gliomas. Therefore, this article reviews the proliferation, apoptosis, invasion, migration, angiogenesis, immune regulation, glycolysis, stemness, and drug resistance changes caused by the dysregulation of lncRNA in gliomas, and summarizes their potential clinical significance in gliomas.
胶质瘤是中枢神经系统最常见的恶性肿瘤，其独特的发病机制常常导致治疗效果和预后不佳。2021年，世界卫生组织（WHO）根据组织学特征和分子变化将胶质瘤分为五类。非编码RNA是一类不编码蛋白质但能在RNA水平发挥生物学功能的RNA，长链非编码RNA（lncRNA）是一类长度超过200个核苷酸的非编码RNA。它受多种转录因子调控，在各种细胞的调控过程中发挥不可或缺的作用。大量研究证实，lncRNA的失调在胶质瘤的发病机制、进展和恶性程度中至关重要。因此，本文综述了lncRNA失调在胶质瘤中引起的增殖、凋亡、侵袭、迁移、血管生成、免疫调节、糖酵解、干性和耐药性变化，并总结了它们在胶质瘤中的潜在临床意义。
