Department of Chemistry, University of Narowal, Narowal, Punjab, 51600, Pakistan.
Division of Energy Technology, Daegu Gyeongbuk Institute of Science & Technology, 333, Techno Jungang-Daero, Hyeonpung-Myeon, Dalseong-Gun, Daegu, 42988, Republic of Korea.
Anal Chim Acta. 2024 Aug 8;1316:342880. doi: 10.1016/j.aca.2024.342880. Epub 2024 Jun 18.
Bioelectronics, a field pivotal in monitoring and stimulating biological processes, demands innovative nanomaterials as detection platforms. Two-dimensional (2D) materials, with their thin structures and exceptional physicochemical properties, have emerged as critical substances in this research. However, these materials face challenges in biomedical applications due to issues related to their biological compatibility, adaptability, functionality, and nano-bio surface characteristics. This review examines surface modifications using covalent and non-covalent-based polymer-functionalization strategies to overcome these limitations by enhancing the biological compatibility, adaptability, and functionality of 2D nanomaterials. These surface modifications aim to create stable and long-lasting therapeutic effects, significantly paving the way for the practical application of polymer-functionalized 2D materials in biosensors and bioelectronics. The review paper critically summarizes the surface functionalization of 2D nanomaterials with biocompatible polymers, including g-CN, graphene family, MXene, BP, MOF, and TMDCs, highlighting their current state, physicochemical structures, synthesis methods, material characteristics, and applications in biosensors and bioelectronics. The paper concludes with a discussion of prospects, challenges, and numerous opportunities in the evolving field of bioelectronics.
生物电子学是监测和刺激生物过程的关键领域，需要创新的纳米材料作为检测平台。二维（2D）材料以其薄型结构和卓越的物理化学特性，成为该研究的关键物质。然而，由于与生物兼容性、适应性、功能性和纳米生物表面特性相关的问题，这些材料在生物医学应用中面临挑战。本综述考察了使用共价和非共价聚合物功能化策略进行表面改性，以通过提高 2D 纳米材料的生物兼容性、适应性和功能性来克服这些限制。这些表面改性旨在创造稳定且持久的治疗效果，为聚合物功能化 2D 材料在生物传感器和生物电子学中的实际应用铺平道路。本文批判性地总结了具有生物相容性聚合物的 2D 纳米材料的表面功能化，包括 g-CN、石墨烯家族、MXene、BP、MOF 和 TMDCs，突出了它们的当前状态、物理化学结构、合成方法、材料特性以及在生物传感器和生物电子学中的应用。本文最后讨论了生物电子学这个不断发展的领域中的前景、挑战和众多机遇。
