Department of Stomatology, the Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, China.
Lipids Health Dis. 2024 Jul 5;23(1):213. doi: 10.1186/s12944-024-02192-z.
This study aimed to explore the associations between triglyceride glucose (TyG) index-related obesity indices and periodontitis within the American population.
This cross-sectional investigation utilized data from the National Health and Nutrition Examination Survey (NHANES) for 2009-2014. The association between the TyG-waist-to-height ratio (TyG-WHtR), TyG-weight-adjusted-waist index (TyG-WWI), TyG-waist circumference (TyG-WC), or TyG-body mass index (TyG-BMI) and periodontitis was investigated utilizing multivariable logistic regression model, subgroup, and dose-response curve analyses.
This study enrolled 4,808 adult participants. Except for TyG-BMI, which did not exhibit a relationship with periodontitis, TyG-WHtR, [odds ratio (OR) (95% confidence interval (CI))] = 2.83 [1.58-5.10], P = 0.002], TyG-WWI [OR (95% CI) = 7.50 (3.06-18.34), P < 0.001], and TyG-WC [OR (95% CI) = 2.12 (1.23-3.64), P = 0.011] were all associated with periodontitis. Participants in the highest quartile displayed an elevated risk of periodontitis relative to their counterparts in the lowest quartile, as evidenced for TyG-WWI [OR (95% CI) = 1.72 (1.26-2.33), P = 0.001] and TyG-WC [OR (95% CI) = 1.50 (1.13-1.99), P = 0.009] in the full adjustment model. Subgroup analyses suggested more pronounced positive associations between these indices and periodontitis in participants who were < 60 years old, had a BMI ≥ 25, and did not have diabetes. The dose-response curve indicated linear responses in these associations.
This investigation identified a significant and stable association between TyG-WHtR, TyG-WWI, or TyG-WC and periodontitis, which implies a robust correlation between high insulin resistance and susceptibility to periodontitis in the American population.
本研究旨在探讨美国人群中甘油三酯-葡萄糖（TyG）指数相关肥胖指数与牙周炎之间的关联。
本横断面研究使用了 2009-2014 年全国健康和营养调查（NHANES）的数据。采用多变量逻辑回归模型、亚组和剂量-反应曲线分析，探讨 TyG-腰围身高比（TyG-WHtR）、TyG-体重调整腰围指数（TyG-WWI）、TyG-腰围（TyG-WC）或 TyG-体重指数（TyG-BMI）与牙周炎之间的关系。
本研究纳入了 4808 名成年参与者。除了 TyG-BMI 与牙周炎无关外，TyG-WHtR[比值比（OR）（95%置信区间（CI））] = 2.83 [1.58-5.10]，P = 0.002]、TyG-WWI[OR（95%CI） = 7.50（3.06-18.34），P < 0.001]和 TyG-WC[OR（95%CI） = 2.12（1.23-3.64），P = 0.009]均与牙周炎相关。与最低四分位数的参与者相比，最高四分位数的参与者发生牙周炎的风险更高，这在 TyG-WWI[OR（95%CI） = 1.72（1.26-2.33），P = 0.001]和 TyG-WC[OR（95%CI） = 1.50（1.13-1.99），P = 0.009]的全调整模型中表现得更为明显。亚组分析表明，在年龄<60 岁、BMI≥25 和无糖尿病的参与者中，这些指数与牙周炎之间的关联更为显著。剂量-反应曲线表明这些关联呈线性关系。
本研究发现 TyG-WHtR、TyG-WWI 或 TyG-WC 与牙周炎之间存在显著且稳定的关联，提示在美人群中，高胰岛素抵抗与牙周炎易感性之间存在较强的相关性。
