Wang Zheng, Huang Bohan, Ding Yixuan, Cao Feng, Li Fei, Li Prof Fei
Department of General Surgery, Xuanwu Hospital, Capital Medical University, No.45 Changchun Street, Xicheng District, Beijing, 100053, China.
Arch Public Health. 2024 Jul 5;82(1):101. doi: 10.1186/s13690-024-01331-3.
Metabolic dysfunction-associated steatotic liver disease(MASLD) is the most common cause of chronic liver disease. Clinical evidences have demonstrated the link between MASLD and the increased risk of cardiovascular disease (CVD) development. We aimed to investigate the relationship between Life's Essential 8 (LE8), an enhanced approach to assessing cardiovascular health(CVH), and MASLD.
Data were extracted from the National Health and Nutrition Examination Survey (NHANES) in 2017-2020 cycles. MASLD was assessed by the latest diagnostic criteria. LE8 scores (range 0-100) were obtained from measurements based on American Heart Association definitions, divided into health factor and health behavior scores. Multivariable logistic and restricted cubic spline models were used to assess the associations.
5646 participants were included based on the inclusion and exclusion criteria, 2616 (46.33%) participants were diagnosed with MASLD. After adjusting for confounding variables, higher LE8 scores were associated with a lower risk of MASLD (OR = 0.19, 95%CI 0.17-0.21; P < 0.001), similar associations were also observed between health behavior and health factor scores with MASLD. Subgroup analyses illustrated that the negative association between LE8 score and MASLD was stronger among younger, non - Hispanic White, and never married participants.
In this nationally representative sample of U.S. adults, LE8 scores, health behavior scores, and health factor scores were negatively associated with the prevalence of MASLD in non-linear fashions. Subjects maintaining ideal health factors and health behaviors are less likely to develop MASLD. Public health policies are needed to advocate healthy behaviors and factors.
代谢功能障碍相关脂肪性肝病（MASLD）是慢性肝病最常见的病因。临床证据表明MASLD与心血管疾病（CVD）发生风险增加之间存在关联。我们旨在研究一种评估心血管健康（CVH）的强化方法——生命必需8要素（LE8）与MASLD之间的关系。
数据来自2017 - 2020年周期的美国国家健康与营养检查调查（NHANES）。采用最新诊断标准评估MASLD。根据美国心脏协会的定义，通过测量获得LE8评分（范围0 - 100），分为健康因素评分和健康行为评分。使用多变量逻辑回归和受限立方样条模型评估相关性。
根据纳入和排除标准纳入5646名参与者，其中2616名（46.33%）参与者被诊断为MASLD。在调整混杂变量后，较高的LE8评分与较低的MASLD风险相关（OR = 0.19，95%CI 0.17 - 0.21；P < 0.001），健康行为评分和健康因素评分与MASLD之间也观察到类似的相关性。亚组分析表明，在年轻、非西班牙裔白人以及未婚参与者中，LE8评分与MASLD之间的负相关更强。
在这个具有全国代表性的美国成年人样本中，LE8评分、健康行为评分和健康因素评分与MASLD的患病率呈非线性负相关。保持理想健康因素和健康行为的个体患MASLD的可能性较小。需要公共卫生政策来倡导健康行为和健康因素。
