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对耐受或易患细胞壁诱导的慢性侵蚀性关节炎的大鼠组织中链球菌细胞壁的测量。

Measurement of streptococcal cell wall in tissues of rats resistant or susceptible to cell wall-induced chronic erosive arthritis.

作者信息

Anderle S K, Allen J B, Wilder R L, Eisenberg R A, Cromartie W J, Schwab J H

出版信息

Infect Immun. 1985 Sep;49(3):836-7. doi: 10.1128/iai.49.3.836-837.1985.

Abstract

The quantity of streptococcal cell wall localized in the joints of rats of strains which are either susceptible (Sprague-Dawley, LEW/N, M520/N) or resistant (Buffalo, WKY/N, F344/N) to cell wall-induced chronic erosive arthritis was measured after intraperitoneal injection of group A streptococcal cell wall fragments. Susceptibility or resistance was not associated with a difference in the amount of cell wall localized in limbs or other tissues. It is concluded that although localization of cell wall in joint tissue is essential for development of arthritis, the relative resistance of certain rat strains reflects genetic regulation of inflammatory response rather than a quantitative difference in localization of cell wall in joints.

摘要

在腹腔注射A组链球菌细胞壁片段后,测定了对细胞壁诱导的慢性侵蚀性关节炎敏感(斯普拉格-道利大鼠、LEW/N、M520/N)或抗性(布法罗大鼠、WKY/N、F344/N)品系大鼠关节中定位的链球菌细胞壁数量。易感性或抗性与肢体或其他组织中定位的细胞壁数量差异无关。得出的结论是,虽然细胞壁在关节组织中的定位对于关节炎的发展至关重要,但某些大鼠品系的相对抗性反映了炎症反应的基因调控,而不是关节中细胞壁定位的数量差异。

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