全身注射链球菌细胞或细胞壁后大鼠的关节炎
Arthritis in rats after systemic injection of streptococcal cells or cell walls.
作者信息
Cromartie W J, Craddock J G, Schwab J H, Anderle S K, Yang C H
出版信息
J Exp Med. 1977 Dec 1;146(6):1585-602. doi: 10.1084/jem.146.6.1585.
Abstract
Further investigation of the biological properties of streptococcal cells and their components has produced a model of erosive synovitis in rats. A single intraperitoneal injection of an aqueous suspension of whole cell sonicate of group A streptococci into Sprague-Dawley rats induced an acute arthritis which evolved into a prolonged inflammatory process characterized by several complete or partial remissions, joint deformity, and ankylosis. The toxic moiety is a peptidoglycan-polysaccharide fragment of the cell wall which persists in tissue. Histologic features of the arthritis include an acute exudative phase followed by an erosive synovitis that leads to destruction of cartilage and subchondral bone and fibrous ankylosis of the joints. The arthropathic properties of whole cell sonicates of several species of streptococci are compared along with studies of the ability of heat-killed, whole cells of groups A, B, and C streptococci to induce arthritis in rats. Whole cells induce arthritis after a latent period of 57-120 days when group A cells are injected and 7-10 days when group B cells are tested.
摘要
对链球菌细胞及其成分生物学特性的进一步研究建立了大鼠侵蚀性滑膜炎模型。向斯普拉格-道利大鼠腹腔内单次注射A组链球菌全细胞超声裂解物的水悬液可诱发急性关节炎，该关节炎会演变成一个长期的炎症过程，其特征为多次完全或部分缓解、关节畸形和强直。毒性部分是细胞壁的肽聚糖-多糖片段，它会在组织中持续存在。关节炎的组织学特征包括急性渗出期，随后是侵蚀性滑膜炎，导致软骨和软骨下骨破坏以及关节纤维性强直。比较了几种链球菌全细胞超声裂解物的关节病特性，并研究了A、B和C组链球菌热灭活全细胞诱导大鼠关节炎的能力。当注射A组细胞时，全细胞在57-120天的潜伏期后诱导关节炎，而测试B组细胞时为7-10天。
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Arthritis in rats after systemic injection of streptococcal cells or cell walls.全身注射链球菌细胞或细胞壁后大鼠的关节炎
J Exp Med. 1977 Dec 1;146(6):1585-602. doi: 10.1084/jem.146.6.1585.
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