Centre of Reproductive Medicine, Department of Obstetrics and Gynaecology, Shengjing Hospital of China Medical University, No. 39 Huaxiang Road, Tiexi District, Shenyang, Liaoning 110022, PR China; Key Laboratory of Reproductive Dysfunction Disease and Fertility Remodelling of Liaoning Province, Shenyang, Liaoning 110022, PR China.
Centre of Reproductive Medicine, Department of Obstetrics and Gynaecology, Shengjing Hospital of China Medical University, No. 39 Huaxiang Road, Tiexi District, Shenyang, Liaoning 110022, PR China; Key Laboratory of Reproductive Dysfunction Disease and Fertility Remodelling of Liaoning Province, Shenyang, Liaoning 110022, PR China.
Ecotoxicol Environ Saf. 2024 Sep 1;282:116685. doi: 10.1016/j.ecoenv.2024.116685. Epub 2024 Jul 5.
Despite the associations of dietary patterns and air pollution with human reproductive health have been demonstrated, the interaction of maternal preconception diet and PM and its components exposure on in vitro fertilization (IVF) treatment outcomes has not been investigated. A total of 2688 couples from an ongoing prospective cohort were included. Principle component analysis with varimax rotation was performed to determine dietary patterns. One-year and 85-day average PM and its components exposure levels before oocyte retrieval were estimated. Generalized linear regression models were conducted to assess the association of dietary patterns and PM and its components exposure with IVF outcomes. Interactive effects of dietary patterns on the association between PM and its components and IVF outcomes were evaluated by stratified analyses based on different dietary patterns. A positive association between the "Fruits-Vegetables-Dairy" pattern and normal fertilization (p-trend = 0.009), Day 3 available embryos (p-trend = 0.048), and top-quality embryos (p-trend = 0.041) was detected. Conversely, women with higher adherence to the "Puffed food-Bakery-Candy" pattern were less likely to achieve Day 3 available embryos (p-trend = 0.042) and top-quality embryos (p-trend = 0.030), clinical pregnancy (p-trend = 0.049), and live birth (p-trend = 0.020). Additionally, increased intake of animal organs and seafood improved the odds of live birth (p-trend = 0.048). Exposure to PM, SO, organic matter (OM), and black carbon (BC) had adverse effects on embryo development and pregnancy outcomes. Furthermore, our findings indicated that the effects of PM components exposure on normal fertilization and embryo quality were modified by the "Grains-Tubers-Legumes". Moreover, moderate intake of animal organs and seafood appeared to attenuate the effect of NO and NH on the risk of early abortion. Our findings provide human evidence of the interaction between dietary patterns and PM exposure on IVF outcomes during preconception, implicating the potential for dietary interventions in infertile women to improve reproductive outcomes under conditions of unavoidable ambient air-pollutant exposure.
尽管已经证明饮食模式和空气污染与人类生殖健康有关，但尚未研究母体孕前饮食和 PM 及其成分暴露与体外受精 (IVF) 治疗结果之间的相互作用。共纳入了来自正在进行的前瞻性队列研究的 2688 对夫妇。采用主成分分析和方差极大旋转法确定饮食模式。估计取卵前一年和 85 天的 PM 及其成分的平均暴露水平。采用广义线性回归模型评估饮食模式和 PM 及其成分暴露与 IVF 结局的关系。基于不同的饮食模式进行分层分析，评估饮食模式对 PM 及其成分与 IVF 结局之间关联的交互作用。“水果-蔬菜-乳制品”模式与正常受精（p 趋势=0.009）、第 3 天可用胚胎（p 趋势=0.048）和优质胚胎（p 趋势=0.041）呈正相关。相反，较高的“膨化食品-面包-糖果”模式的女性更不可能获得第 3 天的可用胚胎（p 趋势=0.042）和优质胚胎（p 趋势=0.030）、临床妊娠（p 趋势=0.049）和活产（p 趋势=0.020）。此外，增加动物器官和海鲜的摄入量增加了活产的几率（p 趋势=0.048）。PM、SO、有机物（OM）和黑碳（BC）的暴露对胚胎发育和妊娠结局有不良影响。此外，我们的研究结果表明，PM 成分暴露对正常受精和胚胎质量的影响受到“谷物-块茎-豆类”的调节。此外，适量摄入动物器官和海鲜似乎可以减轻 NO 和 NH 对早期流产风险的影响。我们的研究结果为饮食模式和 PM 暴露对体外受精结果的相互作用提供了人类证据，提示在不可避免的环境空气污染物暴露下，饮食干预可能改善不孕女性的生殖结局。
