老年人口腔功能低下与唾液生物标志物的关系：一项横断面研究。
Relationship between oral hypofunction and salivary biomarkers in older adults: a cross-sectional study.
机构信息
Department of Periodontology and Endodontology, Tokushima University Graduate School of Biomedical Sciences, 3-18-15 Kuramoto-Cho, Tokushima, 770-8504, Japan.
Department of Hygiene and Oral Health Science, Tokushima University Graduate School of Biomedical Sciences, 3-18-15 Kuramoto-Cho, Tokushima, 770-8504, Japan.
出版信息
BMC Oral Health. 2024 Jul 6;24(1):766. doi: 10.1186/s12903-024-04556-4.
BACKGROUND
Oral health problems have increased among older adults. Oral hypofunction is characterized by seven signs and symptoms: oral uncleanness, oral dryness, decline in occlusal force, decline in the movement function of the tongue and lips, decline in tongue pressure, decline in masticatory function, and decline in swallowing function, the latter being a significant risk factors for oral frailty. Recent research has suggested that salivary biomarkers can be used to assess not only oral diseases, including dental caries and periodontitis, but also systemic diseases, such as cancer and diabetes mellitus. This cross-sectional study investigated the relationship between oral hypofunction and the levels of salivary biomarkers.
METHODS
In total, 116 patients, aged 65 years or older, were included in this cross-sectional study. If three or more signs or symptoms in seven kinds of tests met the criteria of each test, oral hypofunction was diagnosed. The levels of biomarkers in the saliva collected from the patients were analyzed using an enzyme-linked immunosorbent assay.
RESULTS
In total, 63.8% of patients were diagnosed with oral hypofunction. Multivariable linear regression analysis showed that calprotectin levels in the saliva were significantly related to oral moisture and masticatory function. Furthermore, 8-OHdG levels in saliva were associated with the movement function of the tongue and lips and oral hygiene level, and salivary AGE correlated only with the movement function of the tongue and lips. Multiple logistic regression analysis revealed that calprotectin levels in the saliva were significantly correlated with the prevalence of oral hypofunction, even after adjusting for age, sex, and periodontal status. However, none of the biomarker levels in the saliva had a significant relationship with the number of examinations outside the reference range.
CONCLUSIONS
Calprotectin, 8-OHdG, and AGE levels are associated with oral hypofunction in older adults.
背景
老年人的口腔健康问题有所增加。口腔功能低下的特征是有七个体征和症状：口腔不洁、口腔干燥、咀嚼力下降、舌和唇运动功能下降、舌压下降、咀嚼功能下降和吞咽功能下降，后者是口腔虚弱的显著危险因素。最近的研究表明，唾液生物标志物不仅可以用于评估口腔疾病，包括龋齿和牙周炎，还可以用于评估系统性疾病，如癌症和糖尿病。本横断面研究调查了口腔功能低下与唾液生物标志物水平之间的关系。
方法
共有 116 名年龄在 65 岁或以上的患者纳入本横断面研究。如果在七项测试中的三项或更多项测试中出现三个或更多个体征或症状符合每项测试的标准，则诊断为口腔功能低下。使用酶联免疫吸附测定法分析从患者采集的唾液中的生物标志物水平。
结果
共有 63.8%的患者被诊断为口腔功能低下。多变量线性回归分析显示，唾液中的钙卫蛋白水平与口腔湿润度和咀嚼功能显著相关。此外，唾液中的 8-OHdG 水平与舌唇运动功能和口腔卫生水平相关，而唾液中的 AGE 仅与舌唇运动功能相关。多变量逻辑回归分析显示，即使在调整年龄、性别和牙周状况后，唾液中的钙卫蛋白水平与口腔功能低下的患病率也显著相关。然而，唾液中任何生物标志物水平与参考范围外的检查次数均无显著关系。
结论
钙卫蛋白、8-OHdG 和 AGE 水平与老年人的口腔功能低下有关。
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