Australian Research Council (ARC) Centre of Excellence in Synthetic Biology, Queen Elizabeth II Medical Centre (QEIIMC), Nedlands, WA, Australia; Telethon Kids Institute, Northern Entrance, Perth Children's Hospital, Nedlands, WA, Australia.
Australian Research Council (ARC) Centre of Excellence in Synthetic Biology, Queen Elizabeth II Medical Centre (QEIIMC), Nedlands, WA, Australia; Telethon Kids Institute, Northern Entrance, Perth Children's Hospital, Nedlands, WA, Australia; Curtin Medical School, Curtin University, Bentley, WA, Australia; Curtin Health Innovation Research Institute, Curtin University, Bentley, WA, Australia.
Trends Endocrinol Metab. 2024 Oct;35(10):872-883. doi: 10.1016/j.tem.2024.06.008. Epub 2024 Jul 6.
The presence of membrane-bound organelles with specific functions is one of the main hallmarks of eukaryotic cells. Organelle membranes are composed of specific lipids that govern their function and interorganelle communication. Discoveries in cell biology using imaging and omic technologies have revealed the mechanisms that drive membrane remodeling, organelle contact sites, and metabolite exchange. The interplay between multiple organelles and their interdependence is emerging as the next frontier for discovery using 3D reconstruction of volume electron microscopy (vEM) datasets. We discuss recent findings on the links between organelles that underlie common functions and cellular pathways. Specifically, we focus on the metabolism of ether glycerophospholipids that mediate organelle dynamics and their communication with each other, and the new imaging techniques that are powering these discoveries.
具有特定功能的膜结合细胞器的存在是真核细胞的主要特征之一。细胞器膜由特定的脂质组成，这些脂质决定了它们的功能和细胞器间的通讯。使用成像和组学技术的细胞生物学发现揭示了驱动膜重塑、细胞器接触位点和代谢物交换的机制。多个细胞器之间的相互作用及其相互依存关系正在成为使用体积电子显微镜 (vEM) 数据集的 3D 重建发现的下一个前沿。我们讨论了关于为常见功能和细胞途径提供基础的细胞器之间联系的最新发现。具体来说，我们专注于介导细胞器动态及其相互通讯的醚甘油磷脂的代谢，以及推动这些发现的新成像技术。
