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老年人维生素D水平降低与听力损失之间的关系。

The Relationship Between Lower Vitamin D Levels and Hearing Loss in Older Adults.

作者信息

Lee Yun Ji, Jung Jun Ho, Chung Jong Woo

机构信息

Department of Otorhinolaryngology-Head and Neck Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

University of Ulsan College of Medicine, Seoul, Korea.

出版信息

J Audiol Otol. 2024 Oct;28(4):252-259. doi: 10.7874/jao.2023.00458. Epub 2024 Jul 9.

Abstract

BACKGROUND AND OBJECTIVES

Age-related hearing loss (ARHL) is a sensorineural disease that is associated with a number of factors. In addition to age, sex, environment, lifestyle, and comorbidities are all known to be related to ARHL as well. The prevalence of ARHL can be reduced by controlling the adjustable factors that cause it. Vitamin D levels are strongly related to calcium metabolism, which can affect ARHL. This study aimed to investigate the association between vitamin D and ARHL.

SUBJECTS AND METHODS

A total of 1,104 subjects aged >65 years were enrolled from the fifth Korean National Health and Nutrition Examination Survey, which was conducted from 2010-2012. Every participant received both an audiological assessment and a nutritional survey. The association between ARHL and serum vitamin D concentration was analyzed using logistic regression analyses with complex sampling adjusted for confounding factors such as alcohol consumption, smoking status, mobility, and bone mineral density.

RESULTS

Our multivariable analysis revealed that males in the group with lower serum levels of vitamin D (< 20 ng/mL) had a higher prevalence of ARHL (odds ratio, 1.638, 95% confidence interval, 1.058-2.538, p=0.027).

CONCLUSIONS

This finding suggests that lower serum levels of vitamin D are associated with ARHL in the older male population.

摘要

背景与目的

年龄相关性听力损失(ARHL)是一种与多种因素相关的感音神经性疾病。除年龄外,性别、环境、生活方式和合并症也都与ARHL有关。通过控制导致ARHL的可调节因素,可以降低其患病率。维生素D水平与钙代谢密切相关,而钙代谢会影响ARHL。本研究旨在探讨维生素D与ARHL之间的关联。

对象与方法

从2010年至2012年进行的第五次韩国国家健康与营养检查调查中,共纳入了1104名年龄大于65岁的受试者。每位参与者都接受了听力评估和营养调查。使用逻辑回归分析,并对饮酒、吸烟状况、活动能力和骨密度等混杂因素进行复杂抽样调整,分析ARHL与血清维生素D浓度之间的关联。

结果

我们的多变量分析显示,血清维生素D水平较低(<20 ng/mL)组中的男性ARHL患病率较高(比值比,1.638;95%置信区间,1.058 - 2.538;p = 0.027)。

结论

这一发现表明,血清维生素D水平较低与老年男性人群的ARHL有关。

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