2010年至2019年年轻女性炎症性肠病的地理和社会人口统计学流行病学
Geographical and sociodemographic epidemiology of inflammatory bowel disease in young females from 2010 to 2019.
作者信息
Danpanichkul Pojsakorn, Duangsonk Kwanjit, Lopimpisuth Chawin, Ho Agnes Hiu-Yan, Fangsaard Panisara, Sukphutanan Banthoon, Pang Yanfang, Chaisrimaneepan Nattanicha, Dejvajara Disatorn, Suenghataiphorn Thanathip, Worapongpaiboon Rinrada, Chaiyakunapruk Nathorn, Lui Rashid N, Kochhar Gursimran Singh, Ng Siew C, Farraye Francis A, Wijarnpreecha Karn
机构信息
Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, TX, USA; Immunology Unit, Department of Microbiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
Department of Microbiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
出版信息
Dig Liver Dis. 2025 Jan;57(1):190-197. doi: 10.1016/j.dld.2024.07.007. Epub 2024 Jul 26.
BACKGROUND AND AIMS
Inflammatory Bowel Disease (IBD) represents a significant health threat worldwide. However, there are deficiencies in large-scale epidemiological research focusing on these issues, especially among young women. We aim to examine the trend of IBD in young females globally.
METHODS
We utilized data from the Global Burden of Disease (GBD) study between 2010 and 2019 to conduct a comprehensive analysis of the prevalence, mortality, and disability-adjusted life years (DALYs) from IBD in young females (15-49 years), stratified by region, nation, and sociodemographic index (SDI).
RESULTS
Globally, there were 1.27 million (95 % UI 1.10 to 1.45 million) cases and 314,120 (95 % UI 240,880 to 395,420) DALYs from IBD in young females in 2019. Geographically, Europe had the highest burden of IBD in young females (n = 421,320). From 2010 to 2019, the prevalence rate increased in Africa (APC 0.34 %, 95 % CI 0.25 to 0.44 %), the Eastern Mediterranean (APC 0.77 %, 95 % CI 0.74 to 0.81 %), Europe (APC 0.48 %, 95 % CI 0.44 to 0.51 %) and the Western Pacific region (APC 1.01 %, 95 % CI 0.89 to 1.14 %). Countries with lower SDI exhibited higher DALYs to prevalence ratio. Over the study period, the percentage of young women with IBD compared to young adults increased by 0.24 %. This percentage varies significantly between countries, from 26 % to 62 %.
CONCLUSION
The burden of IBD in young females is high and increasing. Countries with lower SDIs generate higher disability per case. This necessitates immediate and inclusive measures to tackle the rising burden of IBD in this vulnerable group.
LAY SUMMARY
From 2010 to 2019, in the largest global epidemiology database, prevalence rates of inflammatory bowel disease in young females increased in many regions. Countries with lower socioeconomic development, as indicated by sociodemographic index, generated a higher burden compared to countries with higher development.
背景与目的
炎症性肠病（IBD）在全球范围内对健康构成重大威胁。然而，针对这些问题的大规模流行病学研究存在不足，尤其是在年轻女性中。我们旨在研究全球年轻女性IBD的趋势。
方法
我们利用2010年至2019年全球疾病负担（GBD）研究的数据，对年轻女性（15 - 49岁）IBD的患病率、死亡率和伤残调整生命年（DALYs）进行全面分析，并按地区、国家和社会人口指数（SDI）进行分层。
结果
2019年，全球年轻女性IBD病例达127万例（95%不确定区间为110万至145万例），DALYs为314,120例（95%不确定区间为240,880至395,420例）。在地理上，欧洲年轻女性IBD负担最高（n = 421,320）。2010年至2019年，非洲（年度百分比变化[APC]为0.34%，95%置信区间为0.25%至0.44%）、东地中海地区（APC为0.77%，95%置信区间为0.74%至0.81%）、欧洲（APC为0.48%，95%置信区间为0.44%至0.51%）和西太平洋地区（APC为1.01%，95%置信区间为0.89%至1.14%）的患病率有所上升。SDI较低的国家DALYs与患病率之比更高。在研究期间，患有IBD的年轻女性占年轻成年人的比例增加了0.24%。该比例在不同国家间差异显著，从26%到62%不等。
结论
年轻女性IBD负担高且呈上升趋势。SDI较低的国家每例病例导致的残疾更高。这需要立即采取全面措施来应对这一弱势群体中IBD负担不断上升的问题。
简要概述
2010年至2019年，在最大的全球流行病学数据库中，许多地区年轻女性炎症性肠病的患病率有所上升。社会人口指数表明，社会经济发展水平较低的国家与发展水平较高的国家相比，负担更重。
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