Alsakarneh Saqr, Hassan Kamal, Jaber Fouad, Mintz Micheal, Zulqarnian Mir, Obeid Ayah, Ghoz Hassan, Hashash Jana G, Farraye Francis A
Department of Medicine, University of Missouri-Kansas City, Kansas City, MO (Saqr Alsakarneh, Fouad Jaber).
Department of Gastroenterology and Hepatology, Weill Cornell University, NY (Kamal Hassan, Micheal Mintz).
Ann Gastroenterol. 2024 Jul-Aug;37(4):427-435. doi: 10.20524/aog.2024.0894. Epub 2024 Jun 14.
Inflammatory bowel disease (IBD) epidemiology has changed rapidly in recent years. We aimed to provide a systematic report of the burden of IBD at a state level in the United States (US), and to study the age- and sex-specific trends of incidence, prevalence and mortality rates for the past 3 decades.
Using the Global Burden of Disease (GBD) 2019 Study Database, we examined the incidence, prevalence and mortality rate, and the disability-adjusted life-years from GBD 2019 at national and state level from 1990-2019.
There was an overall decrease in incidence and prevalence rates of IBD in the US from 1990-2019, while a simultaneous increase in the overall mortality rates was identified. However, a distinct trend of increasing incidence and prevalence rates emerged starting in 2000, with incidence rates rising from 21 cases per 100,000 persons in 2000 to 23 cases per 100,000 persons in 2019. From 1990-2019, incidence and prevalence decreased in males at a higher rate than in females. However, mortality rates increased more in females than males. Incidence rates were highest in Midwestern and Eastern states, and were lowest across the northern Great Plains and Western states, with the highest incidence noted in Michigan (31 cases per 100,000 persons). California had the greatest decrease in incidence rates from 1990-2019 (-63.3%).
Our results concerning recent trends and geographic variations in IBD offer policymakers crucial insights for informed decision-making in policy, research, and investment, facilitating more effective strategies and allocation of resources.
近年来，炎症性肠病（IBD）的流行病学发生了迅速变化。我们旨在提供一份关于美国州一级IBD负担的系统报告，并研究过去30年中发病率、患病率和死亡率的年龄及性别特异性趋势。
利用全球疾病负担（GBD）2019研究数据库，我们研究了1990 - 2019年美国国家和州一级的发病率、患病率、死亡率以及GBD 2019中的伤残调整生命年。
1990 - 2019年美国IBD的发病率和患病率总体下降，而总体死亡率同时上升。然而，从2000年开始出现了发病率和患病率上升的明显趋势，发病率从2000年的每10万人21例上升至2019年的每10万人23例。1990 - 2019年，男性发病率和患病率的下降速度高于女性。然而，女性死亡率的上升幅度高于男性。发病率在中西部和东部各州最高，在大平原北部和西部各州最低，密歇根州的发病率最高（每10万人31例）。1990 - 2019年加利福尼亚州的发病率下降幅度最大（-63.3%）。
我们关于IBD近期趋势和地理差异的结果为政策制定者在政策、研究和投资方面的明智决策提供了关键见解，有助于制定更有效的策略和资源分配。
