Danpanichkul Pojsakorn, Pang Yanfang, Vuthithammee Chawinthorn, Dejvajara Disatorn, Dutta Priyata, Laoveeravat Passisd, Al Ta'ani Omar, Ho Agnes Hy, Pan Chun Wei, Tang Nicole Shu Ying, Suparan Kanokphong, Lui Rashid N, Kim Donghee, Ng Siew C, Kochhar Gursimran Singh, Farraye Francis A, Wijarnpreecha Karn
Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, TX, USA.
Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, Guangxi, China.
Dig Dis Sci. 2025 Mar 19. doi: 10.1007/s10620-025-08976-2.
As the United States population ages, the incidence and prevalence of inflammatory bowel disease (IBD) among older adults are on the rise.
This study provides updated estimates of the IBD burden in older adults and examines changes from 2000 to 2021.
We analyzed data on IBD incidence, prevalence, and disability-adjusted life years (DALYs) in older adults (> 70 years) in the United States from the Global Burden of Disease Study 2021, stratified by sex and state. Using the Joinpoint regression model, we evaluated age-standardized rate changes from 2000 to 2021.
The study estimated 11,250 new cases, 180,880 prevalent cases, and 80,410 DALYs from IBD in older adults in the United States in 2021. In 2021, older adults-onset represented 15% of the total IBD population in the United States, a 3% increase since 2000. Between 2000 and 2021, the incidence (Annual percent change [APC]: 0.58%, 95%CI 0.50 to 0.66%) and DALYs rates (APC: 0.34%, 95%CI 0.07 to 0.62%) increased, while the prevalence rates remained stable. Incidence rate increased at a higher extent in older adults-onset IBD in females compared to that of males. Forty-seven states experienced increased older adults-onset IBD incidence rates during this period.
From 2000 to 2021, the incidence and disability rates of older adults-onset IBD increased in the United States. Although older males initially had higher incidence rates, the rates have disproportionately increased among older females. The proportion of older adults-onset IBD cases and related disability has also grown, highlighting the urgent need for strategies to address the rising IBD burden in older adults.
随着美国人口老龄化，老年人炎症性肠病（IBD）的发病率和患病率正在上升。
本研究提供了老年人IBD负担的最新估计，并考察了2000年至2021年的变化情况。
我们分析了《2021年全球疾病负担研究》中美国70岁以上老年人IBD发病率、患病率和伤残调整生命年（DALY）的数据，按性别和州进行分层。使用Joinpoint回归模型，我们评估了2000年至2021年年龄标准化率的变化。
该研究估计2021年美国老年人IBD有11250例新发病例、180880例现患病例和80410个DALY。2021年，老年人发病的IBD占美国IBD总人口的15%，自2000年以来增加了3%。2000年至2021年期间，发病率（年度百分比变化[APC]：0.58%，95%CI 0.50至0.66%）和DALY率（APC：0.34%，95%CI 0.07至0.62%）上升，而患病率保持稳定。与男性相比，女性老年人发病的IBD发病率上升幅度更大。在此期间，47个州老年人发病的IBD发病率有所上升。
2000年至2021年，美国老年人发病的IBD发病率和伤残率上升。尽管老年男性最初发病率较高，但老年女性中的发病率增长更为显著。老年人发病的IBD病例及相关伤残的比例也有所增加，凸显了迫切需要采取策略来应对老年人中不断上升的IBD负担。
