Zhang Rongqi, Lu Ying, Bian Zilong, Zhou Siyun, Xu Liying, Jiang Fangyuan, Yuan Shuai, Tan Xiao, Chen Xiangjun, Ding Yuan, Li Xue
Department of Big Data in Health Science School of Public Health and the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Institute of Environmental Medicine, Karolinska Institutet, Solna, Stockholm, Sweden.
iScience. 2024 May 9;27(6):109931. doi: 10.1016/j.isci.2024.109931. eCollection 2024 Jun 21.
Large prospective studies are required to better elucidate the associations of physical activity, sedentary behaviors (SBs), and sleep with overall cancer and site-specific cancer risk, accounting for the interactions with genetic predisposition. The study included 360,271 individuals in UK Biobank. After a median follow-up of 12.52 years, we found higher total physical activity (TPA) level and higher sleep scores were related to reduced risk of cancer while higher SB level showed a positive association with cancer. Compared with high TPA-healthy sleep group and low SB-healthy sleep group, low TPA-poor sleep group and high SB-poor sleep group had the highest risk for overall cancer, breast cancer, and lung cancer. Adherence to a more active exercise pattern was associated with a lower risk of cancer irrespective of genetic risk. Our study suggests that improving the quality of sleep and developing physical activity habits might yield benefits in mitigating the cancer risk.
需要开展大规模前瞻性研究，以更好地阐明体力活动、久坐行为（SBs）和睡眠与总体癌症以及特定部位癌症风险之间的关联，并考虑与遗传易感性的相互作用。该研究纳入了英国生物银行中的360,271名个体。在中位随访12.52年后，我们发现较高的总体力活动（TPA）水平和较高的睡眠评分与癌症风险降低相关，而较高的SB水平与癌症呈正相关。与高TPA-健康睡眠组和低SB-健康睡眠组相比，低TPA-睡眠差组和高SB-睡眠差组患总体癌症、乳腺癌和肺癌的风险最高。无论遗传风险如何，坚持更积极的运动模式都与较低的癌症风险相关。我们的研究表明，改善睡眠质量和养成体力活动习惯可能有助于降低癌症风险。
