Hornsleth A, Bech-Thomsen N, Friis B
J Med Virol. 1985 Aug;16(4):321-8. doi: 10.1002/jmv.1890160404.
The IgG-subclass specific antibody response was investigated in primary RS-virus infections in infants and small children by using an ELISA with monoclonal antibodies against the four human IgG subclasses. When 78 serum samples obtained from 21 patients during the first 3-4 mo following the onset of illness were studied, only IgG-1 and IgG-3 antibodies could be detected. Both of these subclass specific antibodies appeared during the second week following the beginning of illness. Approximately 4 wk after the onset of illness, IgG-1 antibodies reached maximum levels, which persisted during the following months. Approximately 3 wk after the onset of illness, IgG-3 antibodies reached maximum levels, which decreased during the following months. Both IgG-1 and IgG-3 antibodies showed neutralizing capacity.
通过使用针对四种人IgG亚类的单克隆抗体的酶联免疫吸附测定法（ELISA），对婴幼儿原发性呼吸道合胞病毒（RS病毒）感染中的IgG亚类特异性抗体反应进行了研究。在疾病发作后的头3 - 4个月内，对从21名患者身上采集的78份血清样本进行研究时，仅能检测到IgG - 1和IgG - 3抗体。这两种亚类特异性抗体均在疾病开始后的第二周出现。发病后约4周，IgG - 1抗体达到最高水平，并在随后几个月持续存在。发病后约3周，IgG - 3抗体达到最高水平，并在随后几个月下降。IgG - 1和IgG - 3抗体均显示出中和能力。
