呼吸道合胞病毒感染中的 Fc 伽马受体：对固有免疫的影响。
Fc gamma receptors in respiratory syncytial virus infections: implications for innate immunity.
机构信息
Department of Pediatrics, Laboratory of Pediatric Infectious Diseases, Radboud University Medical Centre, Nijmegen, The Netherlands; Nijmegen Institute for Infection, Inflammation and Immunity, Radboud University Medical Centre, Nijmegen, The Netherlands.
出版信息
Rev Med Virol. 2014 Jan;24(1):55-70. doi: 10.1002/rmv.1773. Epub 2013 Nov 14.
Abstract
RSV infections are a major burden in infants less than 3 months of age. Newborns and infants express a distinct immune system that is largely dependent on innate immunity and passive immunity from maternal antibodies. Antibodies can regulate immune responses against viruses through interaction with Fc gamma receptors leading to enhancement or neutralization of viral infections. The mechanisms underlying the immunomodulatory effect of Fc gamma receptors on viral infections have yet to be elucidated in infants. Herein, we will discuss current knowledge of the effects of antibodies and Fc gamma receptors on infant innate immunity to RSV. A better understanding of the pathogenesis of RSV infections in young infants may provide insight into novel therapeutic strategies such as vaccination.
摘要
RSV 感染是 3 个月以下婴儿的主要负担。新生儿和婴儿表达一种独特的免疫系统，主要依赖于先天免疫和来自母体抗体的被动免疫。抗体可以通过与 Fcγ 受体相互作用来调节针对病毒的免疫反应，从而增强或中和病毒感染。Fcγ 受体对病毒感染的免疫调节作用的机制在婴儿中尚未阐明。本文将讨论抗体和 Fcγ 受体对 RSV 引起的婴儿先天免疫的影响。更好地了解婴幼儿 RSV 感染的发病机制可能为新的治疗策略（如疫苗接种）提供思路。
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