Welliver R C
Department of Pediatrics, State University of New York at Buffalo.
Clin Microbiol Rev. 1988 Jan;1(1):27-39. doi: 10.1128/CMR.1.1.27.
Respiratory syncytial virus (RSV) infection is a major cause of serious lower respiratory disease in infancy and early childhood. The unique pathogenesis of lower respiratory illness due to RSV offers some intriguing clues to the role of the human immune system in both protection against and development of respiratory illness. More than any other virus, rapid diagnostic techniques have been especially successful in identifying RSV infection. Many of these techniques could be easily adaptable to diagnosis of influenza virus infection and other agents. Finally, ribavirin therapy of RSV infection represents one of the few instances in which antiviral therapy has been shown to be effective for respiratory illnesses. Fundamental observations in these areas in the case of RSV infection open up new and exciting pathways for investigation of respiratory infection due to other viral, chlamydial, and mycoplasmal agents.
呼吸道合胞病毒（RSV）感染是婴幼儿严重下呼吸道疾病的主要病因。RSV所致下呼吸道疾病独特的发病机制为人类免疫系统在预防和引发呼吸道疾病中的作用提供了一些有趣的线索。与其他任何病毒相比，快速诊断技术在识别RSV感染方面尤为成功。其中许多技术可轻松适用于流感病毒感染及其他病原体的诊断。最后，利巴韦林治疗RSV感染是抗病毒治疗已被证明对呼吸道疾病有效的少数实例之一。在RSV感染病例中这些领域的基础观察为研究其他病毒、衣原体和支原体病原体引起的呼吸道感染开辟了新的、令人兴奋的途径。
